Source:http://linkedlifedata.com/resource/pubmed/id/15646657
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2005-1-13
|
| pubmed:abstractText |
Cytomegalovirus (CMV)-specific immune reconstitution early after stem cell transplantation (SCT) was evaluated prospectively by detecting CD8+ T-cells, which recognize the peptide QYDPVAALF in the context of HLA-A*2402. Fifteen allogeneic SCT recipients were included in the study. All recipients and donors were seropositive for CMV and had the HLA-A*2402 allele. CMV-specific T-cells were detected as early as 1 month after transplantation, and their numbers increased to peak levels 2 to 5 months after transplantation. The numbers of CMV-specific T-cells in patients who developed grade II to IV acute graft-versus-host disease (GVHD) and received corticosteroids for acute GVHD were low in the early period after allogeneic SCT. There was a trend toward earlier reconstitution of CMV-specific CD8+ T-cells in allogeneic peripheral blood SCT (PBSCT) patients than in allogeneic bone marrow transplantation patients. The contribution of T-cells in the graft to the recovery of CMV-specific immune responses was also suggested by the finding that the reconstitution of CMV-specific CD8+ T-cells was delayed in CD34-selected autologous PBSCT compared with unpurged autologous PBSCT. The reconstitution of CMV-specific CD8+ T-cells was delayed in patients with CMV disease or recurrent CMV reactivation. These observations suggest that the detection of CMV-specific T-cells with an HLA-peptide tetramer is useful to assess immune reconstitution against CMV and to identify patients at risk for CMV disease or recurrent CMV reactivation after SCT.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0925-5710
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| pubmed:author |
pubmed-author:AokiKenichiK,
pubmed-author:GondoHisashiH,
pubmed-author:HaradaMineM,
pubmed-author:HenzanHidehoH,
pubmed-author:HiguchiMasakazuM,
pubmed-author:HimejiDaisukeD,
pubmed-author:HitoshiNakashimaN,
pubmed-author:HoriuchiTakahikoT,
pubmed-author:InabaShuichiS,
pubmed-author:IshikawaFumihikoF,
pubmed-author:KamezakiKenjiroK,
pubmed-author:KamimuraTomohikoT,
pubmed-author:KandaYoshinobuY,
pubmed-author:KatoKojiK,
pubmed-author:KuroiwaMikaM,
pubmed-author:KuzushimaKiyotakaK,
pubmed-author:MiyamotoToshihiroT,
pubmed-author:NagafujiKojiK,
pubmed-author:NumataAkihikoA,
pubmed-author:OtsukaTakeshiT,
pubmed-author:ShibuyaTsunefumiT,
pubmed-author:ShimodaKazuyaK,
pubmed-author:TakaseKenK,
pubmed-author:TanimotoTetsuyaT,
pubmed-author:TsukamotoHiroshiH,
pubmed-author:TsurumiTatsuyaT
|
| pubmed:issnType |
Print
|
| pubmed:volume |
80
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
441-8
|
| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15646657-Adrenal Cortex Hormones,
pubmed-meshheading:15646657-Adult,
pubmed-meshheading:15646657-Aged,
pubmed-meshheading:15646657-Antigens, CD34,
pubmed-meshheading:15646657-CD8-Positive T-Lymphocytes,
pubmed-meshheading:15646657-Cell Proliferation,
pubmed-meshheading:15646657-Cytomegalovirus,
pubmed-meshheading:15646657-Cytomegalovirus Infections,
pubmed-meshheading:15646657-Female,
pubmed-meshheading:15646657-Graft vs Host Disease,
pubmed-meshheading:15646657-HLA-A Antigens,
pubmed-meshheading:15646657-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:15646657-Humans,
pubmed-meshheading:15646657-Leukemia, Lymphoid,
pubmed-meshheading:15646657-Leukemia, Myeloid,
pubmed-meshheading:15646657-Lymphoma, Non-Hodgkin,
pubmed-meshheading:15646657-Male,
pubmed-meshheading:15646657-Middle Aged,
pubmed-meshheading:15646657-Oligopeptides,
pubmed-meshheading:15646657-Transplantation, Homologous
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Reconstitution of HLA-A*2402-restricted cytomegalovirus-specific T-cells following stem cell transplantation.
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| pubmed:affiliation |
Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan. gondo@hamanomachi.jp
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| pubmed:publicationType |
Journal Article
|