Source:http://linkedlifedata.com/resource/pubmed/id/15645433
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2005-3-21
|
| pubmed:abstractText |
Chemokine receptors mediate the migration of lymphocytes through binding of their ligands. CXCR3 is expressed in Th1 T cells; however, CXCR3 was recently reported in B-cell mucosa-associated lymphoid tissue (MALT)-type lymphoma and splenic marginal zone lymphoma. To investigate whether CXCR3-positive B lymphocytes in peripheral blood (PB) migrate to MALT and spleen, and whether the lymphoma clone is present in PB, we studied 16 cases of MALT lymphoma. In MALT cases, CXCR3-positive B lymphocytes in PB could migrate to MIG, the CXCR3 ligand. Immunohistochemical analysis showed that MALT lymphoma cells expressed CXCR3, whereas epithelial glands and/or stromal cells expressed MIG. In the PCR analysis for VH gene rearrangements, MALT lymphoma showed monoclonal or oligoclonal bands. In addition, in 8 of 16 MALT cases, the VH gene rearrangement of MALT lymphoma had the same bands as the CXCR3-positive B lymphocytes in PB. In 4 cases, the same clones of DNA sequences were confirmed in MALT lymphoma and CXCR3-positive B lymphocytes of PB. The findings support the theory that CXCR3-positive B lymphocytes in PB of MALT patients belong to the lymphoma clone and migrate to MIG-expressing mucosa-associated lymphoid tissue. It seemed to be associated with the dissemination of MALT lymphoma.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CXCL9 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CXCR3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL9,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CXC,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR3,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0020-7136
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
10
|
| pubmed:volume |
114
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
896-901
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15645433-Adult,
pubmed-meshheading:15645433-Aged,
pubmed-meshheading:15645433-B-Lymphocytes,
pubmed-meshheading:15645433-Case-Control Studies,
pubmed-meshheading:15645433-Cell Movement,
pubmed-meshheading:15645433-Chemokine CXCL9,
pubmed-meshheading:15645433-Chemokines, CXC,
pubmed-meshheading:15645433-Female,
pubmed-meshheading:15645433-Gene Expression Profiling,
pubmed-meshheading:15645433-Humans,
pubmed-meshheading:15645433-Immunohistochemistry,
pubmed-meshheading:15645433-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:15645433-Ligands,
pubmed-meshheading:15645433-Lymphoma, B-Cell, Marginal Zone,
pubmed-meshheading:15645433-Male,
pubmed-meshheading:15645433-Middle Aged,
pubmed-meshheading:15645433-Mucous Membrane,
pubmed-meshheading:15645433-Polymerase Chain Reaction,
pubmed-meshheading:15645433-Receptors, CXCR3,
pubmed-meshheading:15645433-Receptors, Chemokine
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
CXCR3-positive B cells found at elevated frequency in the peripheral blood of patients with MALT lymphoma are attracted by MIG and belong to the lymphoma clone.
|
| pubmed:affiliation |
Department of Pathology, School of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|