Linked Life Data

15643866

Source:http://linkedlifedata.com/resource/pubmed/id/15643866

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-1-12
pubmed:abstractText
During the course of the study of the hydrothermal stability of alanine oligopeptides, a small amount of oligopeptides longer than the starting oligopeptides was found in the reaction products. On the basis of this unexpected finding and the investigation of the reaction mechanism, the elongation of oligopeptides using (Ala)3, (Ala)4, and (Ala)5 was attempted in aqueous solution at 275-310 degrees C within the second time range using a microflow reactor system. The elongation of (Ala)4 and (Ala)5 succeeded in the presence of an excess amount of Ala monomer. This is probably due to the fact that the elongation rate is competitive or somewhat faster than the degradation of peptide bonding. On the contrary, the elongation of (Ala)3 was not possible since it was immediately converted to diketopiperazine.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0002-7863
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
127
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
522-3
pubmed:dateRevised
2008-1-17
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Consecutive elongation of alanine oligopeptides at the second time range under hydrothermal conditions using a microflow reactor system.
pubmed:affiliation
Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, Gakuen-cho 1-1, Sakai, Osaka, Japan 599-8531. kawamura@chem.osakafu-u.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't