| pubmed-article:15643740 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15643740 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:15643740 | lifeskim:mentions | umls-concept:C0034716 | lld:lifeskim |
| pubmed-article:15643740 | lifeskim:mentions | umls-concept:C0008838 | lld:lifeskim |
| pubmed-article:15643740 | lifeskim:mentions | umls-concept:C0025405 | lld:lifeskim |
| pubmed-article:15643740 | lifeskim:mentions | umls-concept:C0235280 | lld:lifeskim |
| pubmed-article:15643740 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:15643740 | pubmed:dateCreated | 2005-1-12 | lld:pubmed |
| pubmed-article:15643740 | pubmed:abstractText | The purpose of this study was to evaluate cisplatin-induced ototoxicity and the protective effects of tiopronin. Twenty-four adult Wistar rats served as subjects and were divided into three groups. Eight rats receiving only saline (group A) were used as controls. Eight rats received cisplatin (2 mg/kg) injections (group B) and eight rats received cisplatin and tiopronin (300 mg/kg) (group C) for 8 consecutive days. Both ears of all animals were tested by DPOAE before treatment and on the 4th and 9th days. Seventy-two hours after the final recording session, all animals were killed, and the left cochleas were prepared for electron microscopy and analysed. DPOAE responses were significantly reduced in group B compared to controls (p<0.05). When tiopronin was added, DPOAE responses were significantly increased compared to those obtained with the administration of cisplatin alone (p<0.05). The cochleogram showed that tiopronin had a significant protective effect in the basal half and in the lower half of the middle turn. We conclude that tiopronin, a drug effective in protecting against cisplatin nephrotoxicity, is also effective in protecting against cisplatin ototoxicity. | lld:pubmed |
| pubmed-article:15643740 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15643740 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15643740 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15643740 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15643740 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15643740 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15643740 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15643740 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:15643740 | pubmed:issn | 1499-2027 | lld:pubmed |
| pubmed-article:15643740 | pubmed:author | pubmed-author:PaludettiGaet... | lld:pubmed |
| pubmed-article:15643740 | pubmed:author | pubmed-author:CadoniGabriel... | lld:pubmed |
| pubmed-article:15643740 | pubmed:author | pubmed-author:FetoniAnna... | lld:pubmed |
| pubmed-article:15643740 | pubmed:author | pubmed-author:QuarantaNicol... | lld:pubmed |
| pubmed-article:15643740 | pubmed:author | pubmed-author:SergiBrunoB | lld:pubmed |
| pubmed-article:15643740 | pubmed:author | pubmed-author:MarcheseRaffa... | lld:pubmed |
| pubmed-article:15643740 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15643740 | pubmed:volume | 43 | lld:pubmed |
| pubmed-article:15643740 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15643740 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15643740 | pubmed:pagination | 465-70 | lld:pubmed |
| pubmed-article:15643740 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:15643740 | pubmed:meshHeading | pubmed-meshheading:15643740... | lld:pubmed |
| pubmed-article:15643740 | pubmed:meshHeading | pubmed-meshheading:15643740... | lld:pubmed |
| pubmed-article:15643740 | pubmed:meshHeading | pubmed-meshheading:15643740... | lld:pubmed |
| pubmed-article:15643740 | pubmed:meshHeading | pubmed-meshheading:15643740... | lld:pubmed |
| pubmed-article:15643740 | pubmed:meshHeading | pubmed-meshheading:15643740... | lld:pubmed |
| pubmed-article:15643740 | pubmed:meshHeading | pubmed-meshheading:15643740... | lld:pubmed |
| pubmed-article:15643740 | pubmed:meshHeading | pubmed-meshheading:15643740... | lld:pubmed |
| pubmed-article:15643740 | pubmed:meshHeading | pubmed-meshheading:15643740... | lld:pubmed |
| pubmed-article:15643740 | pubmed:meshHeading | pubmed-meshheading:15643740... | lld:pubmed |
| pubmed-article:15643740 | pubmed:meshHeading | pubmed-meshheading:15643740... | lld:pubmed |
| pubmed-article:15643740 | pubmed:meshHeading | pubmed-meshheading:15643740... | lld:pubmed |
| pubmed-article:15643740 | pubmed:meshHeading | pubmed-meshheading:15643740... | lld:pubmed |
| pubmed-article:15643740 | pubmed:meshHeading | pubmed-meshheading:15643740... | lld:pubmed |
| pubmed-article:15643740 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15643740 | pubmed:articleTitle | The protective role of tiopronin in cisplatin ototoxicity in Wistar rats. | lld:pubmed |
| pubmed-article:15643740 | pubmed:affiliation | Institute of Otolaryngology, Catholic University of Rome, Rome, Italy. afetoni@unicatt.it | lld:pubmed |
| pubmed-article:15643740 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15643740 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
