Linked Life Data

15643094

Source:http://linkedlifedata.com/resource/pubmed/id/15643094

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2005-1-11
pubmed:abstractText
Risperidone is an atypical antipsychotic agent with efficacy for both positive and negative symptoms of schizophrenia. Risperidone is a potent dopamine D3 antagonist and agonism at D3 sites induces behavioral suppression in rodents. We thus hypothesized that D3 antagonism may contribute to response to risperidone in negative symptoms. This study aimed to explore the influence of the Ser9Gly polymorphism of the dopamine D3 receptor (DRD3) gene on response to risperidone after controlling for nongenetic factors. One hundred twenty-three Han Chinese patients with acutely exacerbated schizophrenia were given risperidone monotherapy for up to 42 days. Clinical manifestations were measured biweekly with Positive and Negative Syndrome Scale and Nurses' Observation Scale for Inpatients Evaluation (for assessment of social functioning). For adjusting the within-subject dependence over repeated assessments, multiple linear regression with generalized estimating equation methods was used to analyze the effects of Ser9Gly polymorphism and other covariates on clinical performance. Compared with patients with the Gly9Gly genotype, those with either Ser9Ser or Ser9Gly had better performance on negative symptoms after control for other prognostic factors (P = 0.0002 and 0.0092, respectively). Patients with the Ser9Ser genotype had better social functioning than those with Gly9Gly (P = 0.0029). The Ser9Gly polymorphism, however, did not significantly affect positive symptoms. Male gender, fewer previous hospitalizations, and higher risperidone dose also predicted better treatment response. These data suggest that the DRD3 Ser9Gly polymorphism or, alternatively, another genetic variation that is in linkage disequilibrium, may influence response to risperidone in negative symptoms and social functioning.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0271-0749
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6-11
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:15643094-Adult, pubmed-meshheading:15643094-Amino Acid Substitution, pubmed-meshheading:15643094-Antipsychotic Agents, pubmed-meshheading:15643094-China, pubmed-meshheading:15643094-DNA, pubmed-meshheading:15643094-Dose-Response Relationship, Drug, pubmed-meshheading:15643094-Female, pubmed-meshheading:15643094-Genotype, pubmed-meshheading:15643094-Glycine, pubmed-meshheading:15643094-Humans, pubmed-meshheading:15643094-Male, pubmed-meshheading:15643094-Polymorphism, Genetic, pubmed-meshheading:15643094-Psychiatric Status Rating Scales, pubmed-meshheading:15643094-Receptors, Dopamine D2, pubmed-meshheading:15643094-Receptors, Dopamine D3, pubmed-meshheading:15643094-Risperidone, pubmed-meshheading:15643094-Schizophrenia, pubmed-meshheading:15643094-Serine, pubmed-meshheading:15643094-Social Behavior
pubmed:year
2005
pubmed:articleTitle
Dopamine D3 receptor Ser9Gly polymorphism and risperidone response.
pubmed:affiliation
Department of Psychiatry and Medical Research, China Medical University Hospital, Taichung, Taiwan. hylane@pchome.com.tw
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't