Linked Life Data

15642791

Source:http://linkedlifedata.com/resource/pubmed/id/15642791

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2005-1-11
pubmed:abstractText
The over-expression of epidermal growth factor receptor (EGFR) and its ligands, epidermal growth factor (EGF) and transforming growth factor-alpha, is a common feature of epithelial carcinomas and correlates with neoplastic progression. Secretory leukocyte protease inhibitor (SLPI), a member of the Kazal superfamily of serine anti-proteases, induces proliferation and promotes malignancy of epithelial cells and is expressed at high levels in multiple tumor types. In the present study, we have demonstrated that EGF increases SLPI expression in the human endometrial epithelial cell line Ishikawa in a dose- and time-dependent manner. We have shown that this effect of EGF occurs, in part, at the level of the SLPI promoter and involves the MAP kinase signaling pathway. We have further shown that EGF promotion of cell proliferation, but not induction of cyclin D1 gene expression, involves SLPI. Our results suggest that the regulation of SLPI expression by EGFR ligand(s) may represent a 'feed-forward' mechanism by which the enhanced proliferative and migratory properties of EGFR over-expressing cancer cells are sustained. Increased SLPI expression is likely an important component of altered EGFR signaling in human tumors and may have significant therapeutic implications in cancer progression.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-0795
pubmed:author
pubmed:issnType
Print
pubmed:volume
184
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
141-51
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:15642791-Carcinoma, pubmed-meshheading:15642791-Cell Line, Tumor, pubmed-meshheading:15642791-Cell Proliferation, pubmed-meshheading:15642791-Dose-Response Relationship, Drug, pubmed-meshheading:15642791-Endometrial Neoplasms, pubmed-meshheading:15642791-Epidermal Growth Factor, pubmed-meshheading:15642791-Epithelial Cells, pubmed-meshheading:15642791-Female, pubmed-meshheading:15642791-Gene Expression Regulation, pubmed-meshheading:15642791-Humans, pubmed-meshheading:15642791-Proteinase Inhibitory Proteins, Secretory, pubmed-meshheading:15642791-Proteins, pubmed-meshheading:15642791-Receptor, Epidermal Growth Factor, pubmed-meshheading:15642791-Secretory Leukocyte Peptidase Inhibitor, pubmed-meshheading:15642791-Time Factors, pubmed-meshheading:15642791-Transfection, pubmed-meshheading:15642791-Transforming Growth Factor alpha
pubmed:year
2005
pubmed:articleTitle
The secretory leukocyte protease inhibitor gene is a target of epidermal growth factor receptor action in endometrial epithelial cells.
pubmed:affiliation
Arkansas Children's Nutrition Center and Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, 1120 Marshall St, Little Rock, Arkansas 72202, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.