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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2005-1-19
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pubmed:abstractText |
We report that B cell-activating factor of the tumor necrosis factor (TNF) family (BAFF) is expressed in the normal human brain at approximately 10% of that in lymphatic tissues (tonsils and adenoids) and is produced by astrocytes. BAFF was regularly detected by enzyme-linked immunosorbent assay in brain tissue lysates and in normal spinal fluid, and in astrocytes by double fluorescence microscopy. Cultured human astrocytes secreted functionally active BAFF after stimulation with interferon-gamma and TNF-alpha via a furin-like protease-dependent pathway. BAFF secretion per cell was manifold higher in activated astrocytes than in monocytes and macrophages. We studied brain lesions with B cell components, and found that in multiple sclerosis plaques, BAFF expression was strongly up-regulated to levels observed in lymphatic tissues. BAFF was localized in astrocytes close to BAFF-R-expressing immune cells. BAFF receptors were strongly expressed in situ in primary central nervous system (CNS) lymphomas. This paper identifies astrocytes as a nonimmune source of BAFF. CNS-produced BAFF may support B cell survival in inflammatory diseases and primary B cell lymphoma.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642740-10079101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642740-10329740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642740-10528220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642740-10934227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642740-11133761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642740-12566413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642740-12796483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642740-12928426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642740-12975458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642740-1356158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642740-14707051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642740-14707116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642740-14975582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642740-15084273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642740-15193029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642740-15223251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642740-15240667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642740-15251127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642740-15263096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642740-3941297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642740-9670944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642740-9727074
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/B-Cell Activating Factor,
http://linkedlifedata.com/resource/pubmed/chemical/B-Cell Activation Factor Receptor,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/TNFRSF13C protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TNFSF13B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1007
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pubmed:author |
pubmed-author:AloisiFrancescaF,
pubmed-author:DerfussTobiasT,
pubmed-author:HessDonna MDM,
pubmed-author:HohlfeldReinhardR,
pubmed-author:KalledSusan LSL,
pubmed-author:KrumbholzMarkusM,
pubmed-author:MeinlEdgarE,
pubmed-author:MonoranuCamelia-MariaCM,
pubmed-author:RosenwaldAndreasA,
pubmed-author:SchraderFrankF,
pubmed-author:SerafiniBarbaraB,
pubmed-author:TheilDiethildeD,
pubmed-author:WekerleHartmutH
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
201
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
195-200
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15642740-Astrocytes,
pubmed-meshheading:15642740-B-Cell Activating Factor,
pubmed-meshheading:15642740-B-Cell Activation Factor Receptor,
pubmed-meshheading:15642740-B-Lymphocytes,
pubmed-meshheading:15642740-Brain,
pubmed-meshheading:15642740-Central Nervous System Neoplasms,
pubmed-meshheading:15642740-Humans,
pubmed-meshheading:15642740-Lymphoma,
pubmed-meshheading:15642740-Membrane Proteins,
pubmed-meshheading:15642740-Multiple Sclerosis,
pubmed-meshheading:15642740-Organ Specificity,
pubmed-meshheading:15642740-RNA, Messenger,
pubmed-meshheading:15642740-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:15642740-Tumor Necrosis Factor-alpha,
pubmed-meshheading:15642740-Up-Regulation
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pubmed:year |
2005
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pubmed:articleTitle |
BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma.
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pubmed:affiliation |
Department of Neuroimmunology, Max-Planck-Institute of Neurobiology, D-82152 Martinsried, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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