Linked Life Data

15642400

Source:http://linkedlifedata.com/resource/pubmed/id/15642400

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-1-11
pubmed:abstractText
Bone marrow from 5 patients with acute myeloid leukemia with inversion 16, inv(16), was studied by a combination of fluorescence activated cell sorting (FACS) and fluorescence in situ hybridization (FISH) to establish the extent of cell-lineage involvement of inv(16). In all cases, interphase FISH demonstrated the inv(16) in 80-92% of blasts, monocytes, granulocytes, and a proportion of B-cells (21-41%). In contrast, inv(16) was not detectable above threshold levels in mature T-cells. The current study provides a direct evidence for the clonal involvement of myeloid lineage cells and B-lymphocytes and suggests that T-cells are not part of the malignant clone in this disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0165-4608
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
156
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
175-8
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Clonality analysis of cell lineages in acute myeloid leukemia with inversion 16.
pubmed:affiliation
Department of Laboratory Hematology, Princess Margaret Hospital, University Health Network, 610 University Avenue, 4-320 Toronto, ON, M5G 2M9, Canada. hong.chang@uhn.on.ca
pubmed:publicationType
Journal Article