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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-1-11
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pubmed:abstractText |
Insulin-like growth factor binding protein-3 (IGFBP-3) differentially modulates breast epithelial cell growth through insulin-like growth factor (IGF)-dependent and IGF-independent pathways and is a direct (IGF-independent) growth inhibitor as well as a mitogen that potentiates EGF (epidermal growth factor) and interacts with HER-2. Previously, high IGFBP-3 levels in breast cancers have been determined by enzyme-linked immunosorbent assay and immunoradiometric assay methods. In vitro, IGFBP-3's mechanisms of action may involve cell membrane binding and nuclear translocation. To evaluate tumour-specific IGFBP-3 expression and its subcellular localisation, this study examined immunohistochemical IGFBP-3 expression in a series of invasive ductal breast cancers (IDCs) with synchronous ductal carcinomas in situ (DCIS) in relation to clinicopathological variables and patient outcome.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-10197608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-10347201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-10646845,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-11566611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-11731427,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-12210764,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-12242693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-12376561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-12433918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-12460779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-1382838,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-14593113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-14735188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-15022276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-15070968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-1656243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-1711920,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-7505235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-7685593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-7690042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-7723550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-8557625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-8609661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-8883411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-9095001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-9325280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-9516082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-9610357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-9660801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-9815544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15642160-9842972
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1465-542X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
R119-29
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15642160-Adult,
pubmed-meshheading:15642160-Aged,
pubmed-meshheading:15642160-Aged, 80 and over,
pubmed-meshheading:15642160-Breast Neoplasms,
pubmed-meshheading:15642160-Carcinoma, Intraductal, Noninfiltrating,
pubmed-meshheading:15642160-Cell Proliferation,
pubmed-meshheading:15642160-Disease-Free Survival,
pubmed-meshheading:15642160-Female,
pubmed-meshheading:15642160-Gene Expression Profiling,
pubmed-meshheading:15642160-Humans,
pubmed-meshheading:15642160-Immunohistochemistry,
pubmed-meshheading:15642160-Insulin-Like Growth Factor Binding Protein 3,
pubmed-meshheading:15642160-Middle Aged,
pubmed-meshheading:15642160-Mitogens,
pubmed-meshheading:15642160-Prognosis,
pubmed-meshheading:15642160-Treatment Outcome
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pubmed:year |
2005
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pubmed:articleTitle |
Immunohistochemical expression of insulin-like growth factor binding protein-3 in invasive breast cancers and ductal carcinoma in situ: implications for clinicopathology and patient outcome.
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pubmed:affiliation |
University of Bristol, Department of Clinical Sciences at South Bristol-Surgery, Bristol Royal Infirmary, Bristol, UK. vesteyhaynes@hotmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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