Linked Life Data

15641566

Source:http://linkedlifedata.com/resource/pubmed/id/15641566

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5-6
pubmed:dateCreated
2005-1-11
pubmed:abstractText
Emerging evidence indicates that prenatal growth relates to common disease in adulthood. Here, we review and embed a selection of advances within this field of research. Focus is on endocrine-metabolic and reproductive facets in girls and young women, who experienced a degree of prenatal growth restraint. Such early restraint has now been linked to variable constellations including the following: hyperinsulinemia; dyslipidemia; central adiposity; exaggerated adrenarche and precocious pubarche; early and rapidly progressive puberty; ovarian hyperandrogenism; elevated serum FSH and/or LH; small uterine and/or ovarian size; and oligo- or an-ovulation. Hyperinsulinemic insulin resistance is thought to be a prime pathogenetic factor. Accordingly, insulin sensitization is among the first therapeutic strategies explored, so far, with promising results.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0302-6469
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
353-82
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Novel insights into the endocrine-metabolic and reproductive consequences of prenatal growth restraint in girls. Girls-born-small become women-born-small.
pubmed:affiliation
Department of Pediatrics-University of Leuven, Heretsraat 49-B 3000 Leuven.
pubmed:publicationType
Journal Article, Review