Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
2005-1-10
pubmed:abstractText
Exposure of mice to a 120 dB SPL broad band click sound for 3 h per day induced expression of hypoxia-inducible factor-1alpha (HIF-1alpha) in the organ of Corti, lateral wall tissue and spiral ganglion cells. In the organ of Corti, HIF-1alpha was expressed in inner and outer hair cells, pillar cells and Deiters' cells, but not in Hensen's cells or the tectorial, Reissner's or basement membrane. HIF-1alpha expression was definitely increased in mice with a permanent threshold shift, where the hearing level did not recover, even after 4 weeks. These results suggest that noise may induce tissue hypoxia in the inner ear and that the further study on the role of HIF-1alpha will be needed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2353-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:15640754-Acoustic Stimulation, pubmed-meshheading:15640754-Animals, pubmed-meshheading:15640754-Auditory Threshold, pubmed-meshheading:15640754-Blotting, Western, pubmed-meshheading:15640754-DNA-Binding Proteins, pubmed-meshheading:15640754-Dose-Response Relationship, Radiation, pubmed-meshheading:15640754-Ear, Inner, pubmed-meshheading:15640754-Gene Expression Regulation, pubmed-meshheading:15640754-Hypoxia-Inducible Factor 1, pubmed-meshheading:15640754-Hypoxia-Inducible Factor 1, alpha Subunit, pubmed-meshheading:15640754-Immunohistochemistry, pubmed-meshheading:15640754-Mice, pubmed-meshheading:15640754-Mice, Inbred BALB C, pubmed-meshheading:15640754-Noise, pubmed-meshheading:15640754-Nuclear Proteins, pubmed-meshheading:15640754-Time Factors, pubmed-meshheading:15640754-Transcription Factors
pubmed:year
2004
pubmed:articleTitle
Accumulation of hypoxia-inducible factor-1alpha in mouse inner ear by noise stimulation.
pubmed:affiliation
Department of Otolaryngology, Asan Medical Center, University of Ulsan, College of Medicine, 388-1 Pungnap-Dong, Songpa-Gu, Seoul, 138-736, Korea. jwchung@amc.seoul.kr
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't