Linked Life Data

15640003

Source:http://linkedlifedata.com/resource/pubmed/id/15640003

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-1-10
pubmed:abstractText
To study the distribution of Eco31I restriction polymorphism in nucleotide -204 of 7alpha-hydroxylase gene(CYP7A1)in Sichuan Han population of China and association of the polymorphism with coronary heart disease(CHD),CYP7A1 genotyping was performed by using PCR-RFLP approach in 183 CHD patients and 101 control subjects. 7alpha-hydroxylase gene allele frequencies of C,A were 0.840 and 0.160 in CHD group and 0.822 and 0.178 in control group,respectively. There was no significant difference in frequencies of allele and genotypes in A-204C polymorphism between CHD group and control group (P>0.05). However, in CHD patients there was significant difference in total cholesterol (TC) levels among CC,CA and AA genotypes (P<0.05) ,and the levels of high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) in CHD patients with AA genotype were lower than those in CHD patients with CC and CA genotypes(P<0.05). In control group there was significant difference in TC levels between CC and CA genotypes (P<0.05) . The frequencies of C,A alleles at A-204C polymorphic site were significantly different from those reported in white people(P<0.05). The results indicating that no direct association was found between the A-204C polymorphism and CHD,but there was significant correlation between this polymorphism and the levels of TC ,and there was significant correlation in CHD patient group between this polymorphism and levels of HDL-C and LDL-C.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0253-9772
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
283-6
pubmed:dateRevised
2009-11-3
pubmed:meshHeading
pubmed-meshheading:15640003-Adult, pubmed-meshheading:15640003-Aged, pubmed-meshheading:15640003-Aged, 80 and over, pubmed-meshheading:15640003-Asian Continental Ancestry Group, pubmed-meshheading:15640003-China, pubmed-meshheading:15640003-Cholesterol, pubmed-meshheading:15640003-Cholesterol, HDL, pubmed-meshheading:15640003-Cholesterol, LDL, pubmed-meshheading:15640003-Cholesterol 7-alpha-Hydroxylase, pubmed-meshheading:15640003-Coronary Disease, pubmed-meshheading:15640003-European Continental Ancestry Group, pubmed-meshheading:15640003-Gene Frequency, pubmed-meshheading:15640003-Genetic Predisposition to Disease, pubmed-meshheading:15640003-Genotype, pubmed-meshheading:15640003-Humans, pubmed-meshheading:15640003-Middle Aged, pubmed-meshheading:15640003-Polymorphism, Single Nucleotide
pubmed:year
2004
pubmed:articleTitle
[Association of 7alpha-hydroxylase gene polymorphism with levels of plasma lipids].
pubmed:affiliation
West China Hospital Sichuan University, Department of Medical Genetics, Division of Morbid Genomics, Key Laboratory of Biotherapy of Human Disease, Ministry of Education, Chendu 610 041, P.R.China. to_zb@126.com
pubmed:publicationType
Journal Article, Comparative Study, English Abstract, Research Support, Non-U.S. Gov't