|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001648,
umls-concept:C0002508,
umls-concept:C0020930,
umls-concept:C0034760,
umls-concept:C0175668,
umls-concept:C0220781,
umls-concept:C0248722,
umls-concept:C0332464,
umls-concept:C0598132,
umls-concept:C1704689,
umls-concept:C1883254,
umls-concept:C1883525,
umls-concept:C1883712,
umls-concept:C1999230,
umls-concept:C2346866
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|
pubmed:issue |
1
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|
pubmed:dateCreated |
2005-1-10
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|
pubmed:abstractText |
Benzylic and allylic organozinc and Grignard reagents have been added to resin-bound imines to provide alpha-branched secondary amines. Many functional groups, including electrophilic groups, were compatible with this methodology. Three modules--a resin-bound primary amine, an aromatic aldehyde, and the organometallic--were independently varied to produce a combinatorial library of alpha-branched secondary amines designed as beta-3 adrenergic receptor agonists.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1520-4766
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
99-108
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
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pubmed:articleTitle |
Addition of benzylic and allylic organozinc and Grignard reagents to resin-bound imines to provide alpha-branched secondary amines bearing a wide variety of functional groups. Utility in the synthesis of beta-3 adrenergic receptor agonists.
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pubmed:affiliation |
Bristol-Myers Squibb Pharmaceutical Research Institute, P O Box 5400, Princeton, New Jersey 08543, USA.
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pubmed:publicationType |
Journal Article
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