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pubmed-article:15638435pubmed:abstractTextS-100 is a structural protein of the central nervous system. An elevated level of S-100 in CSF is generally considered to be a marker of nervous tissue damage. The presence of this protein in blood serum points to the functional and/or morphological disruption of the blood-brain barrier. We measured S-100 in the cerebrospinal fluid and blood of children with two of the most often observed pathological states in child neurology--internal hydrocephalus and epilepsy. High levels of S-100 in CSF were detectable in children with internal hydrocephalus. Increased blood levels of S-100 protein were detectable in both groups of paediatric patients. Our preliminary results indicate neuronal damage in internal hydrocephalus and morphological and/or functional disturbances of the blood-brain barrier (their increased permeability) in both above mentioned disabilities.lld:pubmed
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pubmed-article:15638435pubmed:authorpubmed-author:SobaniecWWlld:pubmed
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pubmed-article:15638435pubmed:authorpubmed-author:LewczukPPlld:pubmed
pubmed-article:15638435pubmed:authorpubmed-author:SendrowskiKKlld:pubmed
pubmed-article:15638435pubmed:volume49 Suppl 1lld:pubmed
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pubmed-article:15638435pubmed:pagination236-8lld:pubmed
pubmed-article:15638435pubmed:dateRevised2006-1-6lld:pubmed
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pubmed-article:15638435pubmed:year2004lld:pubmed
pubmed-article:15638435pubmed:articleTitleS-100 protein as marker of the blood-brain barrier disruption in children with internal hydrocephalus and epilepsy--a preliminary study.lld:pubmed
pubmed-article:15638435pubmed:affiliationDepartment of Child Neurology & Rehabilitation, Medical University of Bialystok, Poland. krsen@mp.pllld:pubmed
pubmed-article:15638435pubmed:publicationTypeJournal Articlelld:pubmed
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