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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1992-5-19
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pubmed:abstractText |
Synthetic oligosaccharides derived from the capsular polysaccharide (PRP) of Haemophilus influenzae type b were conjugated to carrier proteins via a thioether linkage. Conjugates were made of trimeric and tetrameric ribose-ribitol-phosphate and tetanus toxoid or diphtheria toxin. All conjugates elicited anti-PRP antibody responses with an increasing immunoglobulin G/immunoglobulin M ratio in adult mice and monkeys. Trimer conjugates elicited lower anti-PRP antibody responses compared with tetramer conjugates. Adult monkeys responded equally well to the tetrameric oligosaccharide-tetanus toxoid conjugate as to the oligosaccharide-CRM197 conjugate (HbOC), which elicits protective levels of serum antibodies in human infants after two or three injections.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1563770-1080151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1563770-19869645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1563770-2000253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1563770-2669102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1563770-2783345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1563770-2784464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1563770-3016088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1563770-3112729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1563770-3259602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1563770-328785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1563770-3306379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1563770-3484506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1563770-3491858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1563770-3499499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1563770-3843705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1563770-4120458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1563770-6332076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1563770-6332863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1563770-6601621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1563770-6610125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1563770-6610736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1563770-6809623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1563770-6967514
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Capsules,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Diphtheria Toxin,
http://linkedlifedata.com/resource/pubmed/chemical/Haemophilus Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Haemophilus influenzae type b...,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Isotypes,
http://linkedlifedata.com/resource/pubmed/chemical/Oligosaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Polysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Polysaccharides, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Tetanus Toxoid,
http://linkedlifedata.com/resource/pubmed/chemical/polyribitol phosphate
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1826-33
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1563770-Animals,
pubmed-meshheading:1563770-Antibodies, Bacterial,
pubmed-meshheading:1563770-Bacterial Capsules,
pubmed-meshheading:1563770-Bacterial Vaccines,
pubmed-meshheading:1563770-Carrier Proteins,
pubmed-meshheading:1563770-Diphtheria Toxin,
pubmed-meshheading:1563770-Female,
pubmed-meshheading:1563770-Haemophilus Vaccines,
pubmed-meshheading:1563770-Haemophilus influenzae,
pubmed-meshheading:1563770-Immunoglobulin Isotypes,
pubmed-meshheading:1563770-Macaca fascicularis,
pubmed-meshheading:1563770-Male,
pubmed-meshheading:1563770-Mice,
pubmed-meshheading:1563770-Oligosaccharides,
pubmed-meshheading:1563770-Polysaccharides,
pubmed-meshheading:1563770-Polysaccharides, Bacterial,
pubmed-meshheading:1563770-Tetanus Toxoid
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pubmed:year |
1992
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pubmed:articleTitle |
Synthetic trimer and tetramer of 3-beta-D-ribose-(1-1)-D-ribitol-5-phosphate conjugated to protein induce antibody responses to Haemophilus influenzae type b capsular polysaccharide in mice and monkeys.
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pubmed:affiliation |
Unit for Bacterial Vaccine Development and Pathogenesis Research, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.
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pubmed:publicationType |
Journal Article
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