Source:http://linkedlifedata.com/resource/pubmed/id/15637423
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2005-3-8
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| pubmed:abstractText |
Excessive flux through the polyol pathway has long been thought to be involved in the pathogenesis of diabetic microvascular complications. Aldose reductase (AR) is the first and rate-limiting enzyme in the pathway that catalyses the reduction of glucose to sorbitol. A frequent C-106T polymorphism in the promoter of the AR gene has been described, which may change the expression of the gene. The aim of the study was to examine if the C-106T polymorphism was associated with diabetic nephropathy.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
1660-2129
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
99
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
e63-7
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| pubmed:meshHeading |
pubmed-meshheading:15637423-Aged,
pubmed-meshheading:15637423-Albuminuria,
pubmed-meshheading:15637423-Aldehyde Reductase,
pubmed-meshheading:15637423-Blood Glucose,
pubmed-meshheading:15637423-Diabetes Mellitus, Type 2,
pubmed-meshheading:15637423-Diabetic Nephropathies,
pubmed-meshheading:15637423-Genetic Predisposition to Disease,
pubmed-meshheading:15637423-Hemoglobin A, Glycosylated,
pubmed-meshheading:15637423-Humans,
pubmed-meshheading:15637423-Middle Aged,
pubmed-meshheading:15637423-Polymorphism, Single Nucleotide,
pubmed-meshheading:15637423-Risk Factors
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| pubmed:year |
2005
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| pubmed:articleTitle |
C-106T polymorphism in promoter of aldose reductase gene is a risk factor for diabetic nephropathy in type 2 diabetes patients with poor glycaemic control.
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| pubmed:affiliation |
Department and Clinic of Internal Medicine, Diabetology and Nephrology, Silesian School of Medicine, Zabrze, Poland. kasiagos@poczta.onet.pl
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| pubmed:publicationType |
Journal Article
|