| pubmed-article:15637055 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15637055 | lifeskim:mentions | umls-concept:C0023418 | lld:lifeskim |
| pubmed-article:15637055 | lifeskim:mentions | umls-concept:C0291573 | lld:lifeskim |
| pubmed-article:15637055 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:15637055 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:15637055 | lifeskim:mentions | umls-concept:C0385242 | lld:lifeskim |
| pubmed-article:15637055 | lifeskim:mentions | umls-concept:C1330957 | lld:lifeskim |
| pubmed-article:15637055 | lifeskim:mentions | umls-concept:C1366587 | lld:lifeskim |
| pubmed-article:15637055 | lifeskim:mentions | umls-concept:C0333516 | lld:lifeskim |
| pubmed-article:15637055 | lifeskim:mentions | umls-concept:C1336646 | lld:lifeskim |
| pubmed-article:15637055 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:15637055 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:15637055 | lifeskim:mentions | umls-concept:C0596311 | lld:lifeskim |
| pubmed-article:15637055 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15637055 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:15637055 | pubmed:dateCreated | 2005-3-14 | lld:pubmed |
| pubmed-article:15637055 | pubmed:abstractText | Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces programmed cell death through the caspase activation cascade and translocation of cleaved Bid (tBid) by the apical caspase-8 to mitochondria to induce oligomerization of multidomain Bax and Bak. However, the roles of prosurvival Bcl-2 family proteins in TRAIL apoptosis remain elusive. Here we showed that, besides the specific cleavage and activation of Bid by caspase-8 and caspase-3, TRAIL-induced apoptosis in Jurkat T cells required the specific cleavage of Mcl-1 at Asp-127 and Asp-157 by caspase-3, while other prototypic antiapoptotic factors such as Bcl-2 or Bcl-X(L) seemed not to be affected. Mutation at Asp-127 and Asp-157 of Mcl-1 led to cellular resistance to TRAIL-induced apoptosis. In sharp contrast to cycloheximide-induced Mcl-1 dilapidation, TRAIL did not activate proteasomal degradation of Mcl-1 in Jurkat cells. We further established for the first time that the C-terminal domain of Mcl-1 became proapoptotic as a result of caspase-3 cleavage, and its physical interaction and cooperation with tBid, Bak, and voltage-dependent anion-selective channel 1 promoted mitochondrial apoptosis. These results suggested that removal of N-terminal domains of Bid by caspase-8 and Mcl-1 by caspase-3 enabled the maximal mitochondrial perturbation that potentiated TRAIL-induced apoptosis. | lld:pubmed |
| pubmed-article:15637055 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15637055 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637055 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15637055 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15637055 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:15637055 | pubmed:author | pubmed-author:SuF HFH | lld:pubmed |
| pubmed-article:15637055 | pubmed:author | pubmed-author:TangHongH | lld:pubmed |
| pubmed-article:15637055 | pubmed:author | pubmed-author:LiYuanY | lld:pubmed |
| pubmed-article:15637055 | pubmed:author | pubmed-author:ShiYongY | lld:pubmed |
| pubmed-article:15637055 | pubmed:author | pubmed-author:WengChangjian... | lld:pubmed |
| pubmed-article:15637055 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15637055 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:15637055 | pubmed:volume | 280 | lld:pubmed |
| pubmed-article:15637055 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15637055 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15637055 | pubmed:pagination | 10491-500 | lld:pubmed |
| pubmed-article:15637055 | pubmed:dateRevised | 2008-7-9 | lld:pubmed |
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