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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-1-6
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pubmed:abstractText |
To combine in the same molecule alpha(1)-adrenoreceptor blocking and antioxidant properties, compounds 2-5 were designed and synthesized. All compounds were effective alpha(1)-adrenoreceptor antagonists and were tested in both functional and binding assays. In addition, compounds 2 and 5 also displayed significant capacity to inhibit intracellular oxidative stress, whereas 3-5 exerted potent antiproliferative activity in lymph node carcinoma of prostate cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
28-31
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15633998-Adrenergic alpha-1 Receptor Antagonists,
pubmed-meshheading:15633998-Adrenergic alpha-Antagonists,
pubmed-meshheading:15633998-Animals,
pubmed-meshheading:15633998-Antioxidants,
pubmed-meshheading:15633998-Biochemistry,
pubmed-meshheading:15633998-CHO Cells,
pubmed-meshheading:15633998-Carcinoma,
pubmed-meshheading:15633998-Cricetinae,
pubmed-meshheading:15633998-Cricetulus,
pubmed-meshheading:15633998-Drug Design,
pubmed-meshheading:15633998-Drug Evaluation, Preclinical,
pubmed-meshheading:15633998-Humans,
pubmed-meshheading:15633998-Male,
pubmed-meshheading:15633998-Prazosin,
pubmed-meshheading:15633998-Prostatic Neoplasms,
pubmed-meshheading:15633998-Rats,
pubmed-meshheading:15633998-Reactive Oxygen Species,
pubmed-meshheading:15633998-Receptors, Adrenergic, alpha-1,
pubmed-meshheading:15633998-Structure-Activity Relationship,
pubmed-meshheading:15633998-Thioctic Acid,
pubmed-meshheading:15633998-Tumor Cells, Cultured,
pubmed-meshheading:15633998-Vas Deferens
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pubmed:year |
2005
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pubmed:articleTitle |
Design, synthesis, and biological evaluation of prazosin-related derivatives as multipotent compounds.
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pubmed:affiliation |
Departments of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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