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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-1-4
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pubmed:abstractText |
The CD4+ CD25+ regulatory T cells play a critical role in controlling autoimmunity, but little is known about their development and maintenance. In this study, we investigated whether CD4+ CD25- cells can convert to CD4+ CD25+ regulatory T cells in vivo under natural conditions. CD4+ CD25- cells from CD45.1+ mice were sorted and transferred into congenic CD45.2+ mice. Converted CD4+ CD25+ cells could be detected in lymphoid organs as early as 1 wk after transfer and by 6 wk after transfer, 5-12% of transferred CD4+ cells expressed CD25. Converted CD4+ CD25+ cells themselves failed to proliferate after stimulation, but could suppress proliferation of responder cells in vitro, and also expressed high levels of Foxp3 mRNA. In addition, CD4+ CD25- cells transferred into thymectomized congenic mice converted to CD4+ CD25+ cells that also suppressed responder cell proliferation in vitro, and expressed high levels of Foxp3 mRNA. Finally, CD4+ CD25- cells transferred into B7-/- mice failed to convert into CD4+ CD25+ cells that exhibit the regulatory phenotype. These data indicate that CD4+ CD25- cells convert into CD4+ CD25+ regulatory T cells spontaneously in vivo and suggest that this conversion process could contribute significantly to the maintenance of the peripheral CD4+ CD25+ regulatory T cell population.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-10228007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-10795741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-10899916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-10899917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-11276200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-11418648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-11514600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-11535631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-11740498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-11812990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-11869690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-12089509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-12119348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-12193715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-12242333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-12522256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-12612578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-12612581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-12766766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-14500627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-14676299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-15032588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-15100259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-15148338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-7636184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-8426109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-8760792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-9405261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-9670041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-9885918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15630140-9914214
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
201
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
127-37
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15630140-Adoptive Transfer,
pubmed-meshheading:15630140-Animals,
pubmed-meshheading:15630140-Antigens, CD80,
pubmed-meshheading:15630140-Autoimmune Diseases,
pubmed-meshheading:15630140-CD4-Positive T-Lymphocytes,
pubmed-meshheading:15630140-Cell Proliferation,
pubmed-meshheading:15630140-DNA Primers,
pubmed-meshheading:15630140-DNA-Binding Proteins,
pubmed-meshheading:15630140-Flow Cytometry,
pubmed-meshheading:15630140-Forkhead Transcription Factors,
pubmed-meshheading:15630140-Lymphoid Tissue,
pubmed-meshheading:15630140-Mice,
pubmed-meshheading:15630140-Mice, Inbred C57BL,
pubmed-meshheading:15630140-Receptors, Interleukin-2,
pubmed-meshheading:15630140-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15630140-T-Lymphocyte Subsets
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pubmed:year |
2005
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pubmed:articleTitle |
Conversion of CD4+ CD25- cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus.
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pubmed:affiliation |
Department of Microbiology and Immunology, University of Louisville Health Science Center, Louisville, KY 40202, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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