Linked Life Data

1563001

Source:http://linkedlifedata.com/resource/pubmed/id/1563001

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9 Suppl
pubmed:dateCreated
1992-5-21
pubmed:abstractText
Lung cancer is now the leading cause of excess mortality among smokers in the United States. The ability to identify smokers with the greatest risk of developing lung cancer would be an important step in reducing lung cancer mortality. Tobacco-specific nitrosamines such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine are important carcinogens in tobacco smoke. These carcinogens require metabolic activation to exert their carcinogenic effects. Methods are described for the measurement of DNA and hemoglobin adducts formed by the metabolites of these nitrosamines. Preliminary evidence is presented that shows that a subpopulation of smokers have elevated levels of DNA and hemoglobin adducts of tobacco-specific nitrosamines. Further work is in progress to test the hypothesis that smokers with elevated levels of tobacco-specific nitrosamine adducts are at increased risk of developing lung cancer.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2698s-2701s
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
DNA and hemoglobin adducts as markers of metabolic activation of tobacco-specific carcinogens.
pubmed:affiliation
Division of Chemical Carcinogenesis, American Health Foundation, Valhalla, New York 10595.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review