| pubmed-article:15629432 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15629432 | lifeskim:mentions | umls-concept:C1511667 | lld:lifeskim |
| pubmed-article:15629432 | lifeskim:mentions | umls-concept:C0017350 | lld:lifeskim |
| pubmed-article:15629432 | lifeskim:mentions | umls-concept:C0537298 | lld:lifeskim |
| pubmed-article:15629432 | lifeskim:mentions | umls-concept:C1414110 | lld:lifeskim |
| pubmed-article:15629432 | lifeskim:mentions | umls-concept:C1521996 | lld:lifeskim |
| pubmed-article:15629432 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:15629432 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15629432 | pubmed:dateCreated | 2005-1-4 | lld:pubmed |
| pubmed-article:15629432 | pubmed:abstractText | Somatic hypermutation (SHM) of immunoglobulin variable (V) region genes occurs in the germinal center (GC) B cells during immune responses, depending on activation-induced cytidine deaminase (AID). SHM is associated with resected double-strand DNA breaks (DSBs) which were shown to occur specifically in rearranged V regions in the GC B cells and CD40-stimulated B cells expressing AID. So far, endonucleases responsible for the DSBs have not been identified. Here we show that DNase gamma, a member of DNase I family of endonucleases, is expressed in GC B cells and CD40-stimulated B cells. Overexpression of DNase gamma in the mutation-competent Ramos B-cell line resulted in a marked increase in the resected but not blunt DSBs in the V region. Conversely, a selective DNase gamma inhibitor, DR396, suppressed the generation of the resected DSBs. These results suggest that DNase gamma is involved in the generation of resected DSBs associated with SHM. | lld:pubmed |
| pubmed-article:15629432 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15629432 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15629432 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15629432 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15629432 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15629432 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15629432 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15629432 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15629432 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15629432 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:15629432 | pubmed:author | pubmed-author:ShiokawaDaisu... | lld:pubmed |
| pubmed-article:15629432 | pubmed:author | pubmed-author:TanumaSei-ich... | lld:pubmed |
| pubmed-article:15629432 | pubmed:author | pubmed-author:YoshimoriAtsu... | lld:pubmed |
| pubmed-article:15629432 | pubmed:author | pubmed-author:KitamuraDaisu... | lld:pubmed |
| pubmed-article:15629432 | pubmed:author | pubmed-author:SunagaSatoshi... | lld:pubmed |
| pubmed-article:15629432 | pubmed:author | pubmed-author:OkamotoMariko... | lld:pubmed |
| pubmed-article:15629432 | pubmed:author | pubmed-author:OkamotoNoriak... | lld:pubmed |
| pubmed-article:15629432 | pubmed:author | pubmed-author:YashiroHisako... | lld:pubmed |
| pubmed-article:15629432 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15629432 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:15629432 | pubmed:volume | 327 | lld:pubmed |
| pubmed-article:15629432 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15629432 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15629432 | pubmed:pagination | 76-83 | lld:pubmed |
| pubmed-article:15629432 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15629432 | pubmed:meshHeading | pubmed-meshheading:15629432... | lld:pubmed |
| pubmed-article:15629432 | pubmed:meshHeading | pubmed-meshheading:15629432... | lld:pubmed |
| pubmed-article:15629432 | pubmed:meshHeading | pubmed-meshheading:15629432... | lld:pubmed |
| pubmed-article:15629432 | pubmed:meshHeading | pubmed-meshheading:15629432... | lld:pubmed |
| pubmed-article:15629432 | pubmed:meshHeading | pubmed-meshheading:15629432... | lld:pubmed |
| pubmed-article:15629432 | pubmed:meshHeading | pubmed-meshheading:15629432... | lld:pubmed |
| pubmed-article:15629432 | pubmed:meshHeading | pubmed-meshheading:15629432... | lld:pubmed |
| pubmed-article:15629432 | pubmed:meshHeading | pubmed-meshheading:15629432... | lld:pubmed |
| pubmed-article:15629432 | pubmed:meshHeading | pubmed-meshheading:15629432... | lld:pubmed |
| pubmed-article:15629432 | pubmed:meshHeading | pubmed-meshheading:15629432... | lld:pubmed |
| pubmed-article:15629432 | pubmed:meshHeading | pubmed-meshheading:15629432... | lld:pubmed |
| pubmed-article:15629432 | pubmed:meshHeading | pubmed-meshheading:15629432... | lld:pubmed |
| pubmed-article:15629432 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15629432 | pubmed:articleTitle | Involvement of DNase gamma in the resected double-strand DNA breaks in immunoglobulin genes. | lld:pubmed |
| pubmed-article:15629432 | pubmed:affiliation | Division of Molecular Biology, Research Institute for Biological Sciences, Tokyo University of Science, 2669 Yamazaki, Noda, Chiba 278-0022, Japan. | lld:pubmed |
| pubmed-article:15629432 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15629432 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:1776 | entrezgene:pubmed | pubmed-article:15629432 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15629432 | lld:entrezgene |
