Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-3-1
pubmed:abstractText
The heat-shock response in humans and other eukaryotes is a highly conserved genetic network that coordinates the cellular response to protein damage and is essential for adaptation and survival of the stressed cell. It involves an immediate and transient activation of heat-shock transcription factor-1 (HSF1) which results in the elevated expression of genes encoding proteins important for protein homeostasis including molecular chaperones and components of the protein degradative machinery. We have developed a mathematical model of the critical steps in the regulation of HSF1 activity to understand how chronic exposure to a stress signal is converted into specific molecular events for activation and feedback regulated attenuation of HSF1. The model is utilized to identify the most sensitive steps in HSF1 activation and to evaluate how these steps affect the expression of molecular chaperones. This analysis allows the formulation of hypotheses about the differences between the heat-shock responses in yeast and humans and generates a model with predictive abilities relevant to diseases associated with the accumulation of damaged and aggregated proteins including cancer and neurodegenerative diseases.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-10504405, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-10583944, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-11312698, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-11344080, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-11447121, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-11536134, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-11598186, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-12082142, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-12114026, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-12468231, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-12747895, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-12932324, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-1429548, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-1458023, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-14668486, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-14732014, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-1643656, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-1936996, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-1986252, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-3062378, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-3159021, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-3211126, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-3306402, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-3437893, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-3600634, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-6384217, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-6791161, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-6814763, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-6947258, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-8122909, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-8441385, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-8451637, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-8455624, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-8598289, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-8631933, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-8689565, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-8816754, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-9009826, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-9121459, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-9267034, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-9476895, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-9483450, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-9499401, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-9727490, http://linkedlifedata.com/resource/pubmed/commentcorrection/15626701-9869631
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0006-3495
pubmed:author
pubmed:issnType
Print
pubmed:volume
88
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1646-58
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Mathematical modeling of the eukaryotic heat-shock response: dynamics of the hsp70 promoter.
pubmed:affiliation
Department of Chemical and Biological Engineering, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Evaluation Studies, Research Support, N.I.H., Extramural, Validation Studies