Linked Life Data

15624913

Source:http://linkedlifedata.com/resource/pubmed/id/15624913

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-12-30
pubmed:abstractText
Three new azamacrocyclic-cyclophane hybrid receptors L(1), L(2), and L(3) have been synthesized that incorporate either 1,4,7,10-tetraazacyclododecane (cyclen) or 1,4,7-triazacyclononane (tacn) unit(s) tethered via a short amidic spacer to an electron donor and a H-bonding crown ether polycycle. The crown ether is designed to act as a host toward biologically relevant guests, whereas the macrocycle can coordinate a zinc(II) or a copper(II) ion. The pK(a) of this bound water in the zinc(II) complex of L(1) and L(2) is approximately 7.5. Isothermal calorimetry experiments carried out on [ZnL(1)(L2)(OH(2))](CF(3)SO(3))(2) and [Zn(2)L(2)(OH(2))(2)](CF(3)SO(3))(4) in buffered water (pH 7.4) at 25 degrees C show that the host strongly binds a series of phosphate derivatives. In comparison, the complex [CuL(3)(OH(2))(2)](CF(3)SO(3))(2) is a poor receptor toward phosphate substrates.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-3263
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
115-23
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Synthesis and binding properties of hybrid cyclophane-azamacrocyclic receptors.
pubmed:affiliation
Molecular Photonics Laboratory, School of Natural Sciences (Chemistry), Bedson Building, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK. A.C.Benniston@ncl.ac.uk
pubmed:publicationType
Journal Article