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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1992-5-19
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pubmed:abstractText |
The effect of photodynamic therapy (PDT) on tumour perfusion in both anaplastic (R3327-AT) and well differentiated (R3327-H) Dunning prostatic tumours was studied using the radiopharmaceutical 99Technetium hexamethylpropyleneamine oxime (99mTc-HMPAO). Tumours in the left flanks of rats (Copenhage x Fischer, F1 hybrids) were treated with interstitial PDT when their volumes reached 2-3 cm3. Qualitative and quantitative data from pre- and post-PDT scintigraphy revealed a light-dose-dependent shut-down of tumour perfusion which was also time-dependent. Maximal shut-down, following a 1,600 J light-dose, occurred about 8 h post-PDT. Light exposure 2 h after the intravenous administration of the photosensitiser (Photofrin II) produced a greater vascular shut-down than did light exposure 24 h after the administration of the drug. Regional differences in perfusion within treated and non-treated tumours were measured by tomographic procedures. Light-dose-dependent volumes of perfusion shut-down were demonstrated in addition to the naturally occurring regional differences in tumour perfusion. This radiopharmaceutical may have future utility for monitoring the clinical treatment of solid tumours with PDT.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1562457-14073009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1562457-1833785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1562457-2139357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1562457-2140411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1562457-2531034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1562457-2733098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1562457-2770633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1562457-2788006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1562457-2831551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1562457-2964655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1562457-2970687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1562457-3157442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1562457-3258369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1562457-3441508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1562457-3697992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1562457-3698010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1562457-3724341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1562457-3786468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1562457-3967232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1562457-3978628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1562457-4009821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1562457-6210430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1562457-6231988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1562457-6431458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1562457-6889915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1562457-6962638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1562457-7378279
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
491-7
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1562457-Animals,
pubmed-meshheading:1562457-Cell Differentiation,
pubmed-meshheading:1562457-Male,
pubmed-meshheading:1562457-Neoplasms, Experimental,
pubmed-meshheading:1562457-Organotechnetium Compounds,
pubmed-meshheading:1562457-Oximes,
pubmed-meshheading:1562457-Photochemotherapy,
pubmed-meshheading:1562457-Prostatic Neoplasms,
pubmed-meshheading:1562457-Radionuclide Imaging,
pubmed-meshheading:1562457-Rats,
pubmed-meshheading:1562457-Technetium Tc 99m Exametazime
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pubmed:year |
1992
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pubmed:articleTitle |
Non-invasive monitoring of photodynamic therapy with 99technetium HMPAO scintigraphy.
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pubmed:affiliation |
Department of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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