Linked Life Data

15624029

Source:http://linkedlifedata.com/resource/pubmed/id/15624029

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-12-29
pubmed:abstractText
In patients with inflammatory bowel diseases (IBD) the immune system leads to the polarization of intestinal immune cells towards a T helper one (Th1) pro-inflammatory response. The immunologic factors intervene in intestinal homeostasis and initiate the development of intestinal mucosal inflammation. Cytokines, which are important regulators of inflammation and repair as wells as leukocyte trafficking have become apparent as key immune molecules in the pathogenesis of IBD. In this review, recent advances in our understanding of the cytokine involvement in inflammation and repair in patients with ulcerative colitis (UC) and Crohn's disease (CD) are discussed. Knowledge of objective evidence of inflammatory activity may allow targeted treatment at an earlier stage to avoid the relapse, as well as assessment of new therapeutic strategies for maintenance of remission.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1221-4167
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
309-16
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Signaling for inflammation and repair in inflammatory bowel disease.
pubmed:affiliation
In Vitro Toxicology Laboratory, Center for Addiction and Mental Health, 33 Russell Street, Room 2035, Toronto, ON M5S 2S1, Canada. mneuman@klaru-baycrest.on.ca
pubmed:publicationType
Journal Article, Review