15623558

Source:http://linkedlifedata.com/resource/pubmed/id/15623558

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0019564, umls-concept:C0152316, umls-concept:C0205147, umls-concept:C0376249, umls-concept:C0439101, umls-concept:C0808080, umls-concept:C1413038, umls-concept:C1704259, umls-concept:C1705922, umls-concept:C1705987, umls-concept:C1948023
pubmed:issue	1
pubmed:dateCreated	2005-1-5
pubmed:abstractText	The subiculum (SB) is the principal target of the axons of the CA1 pyramidal cells and serves as the final relay in the trisynaptic loop between the entorhinal cortex and the hippocampus. We have examined synaptic plasticity in the synaptic pathway between the CA1 pyramidal cells and the SB in hippocampal slices and compared it under the same experimental condition with the synaptic plasticity in Shaffer collateral pathway (CA3-CA1). We find that the frequency response curve of synaptic strength induced by prolonged low-frequency stimulation (1-5 Hz) is systematically up-shifted from Shaffer collateral to the CA1-SB pathway. The up-regulation of synaptic strength is mediated by the activity-dependent modulation by beta-adrenergic transmission. Because the CA3-CA1 and the CA1-SB synaptic pathways are in series and the beta-adrenergic modulation is region-specific, this modulation seems to be involved in the selective control of signal transmission between the different regions of hippocampus.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/5P50 MH 50733
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/15623558-10595521, http://linkedlifedata.com/resource/pubmed/commentcorrection/15623558-10985284, http://linkedlifedata.com/resource/pubmed/commentcorrection/15623558-11153714, http://linkedlifedata.com/resource/pubmed/commentcorrection/15623558-1727001, http://linkedlifedata.com/resource/pubmed/commentcorrection/15623558-3607449, http://linkedlifedata.com/resource/pubmed/commentcorrection/15623558-6324206, http://linkedlifedata.com/resource/pubmed/commentcorrection/15623558-7903643, http://linkedlifedata.com/resource/pubmed/commentcorrection/15623558-8158272, http://linkedlifedata.com/resource/pubmed/commentcorrection/15623558-8380851, http://linkedlifedata.com/resource/pubmed/commentcorrection/15623558-8483980, http://linkedlifedata.com/resource/pubmed/commentcorrection/15623558-8816710, http://linkedlifedata.com/resource/pubmed/commentcorrection/15623558-9597159, http://linkedlifedata.com/resource/pubmed/commentcorrection/15623558-9630529, http://linkedlifedata.com/resource/pubmed/commentcorrection/15623558-9704982, http://linkedlifedata.com/resource/pubmed/commentcorrection/15623558-9753168
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7505876
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta
pubmed:status	MEDLINE
pubmed:month	Jan
pubmed:issn	0027-8424
pubmed:author	pubmed-author:HuangYan-YouYY, pubmed-author:KandelEric RER
pubmed:issnType	Print
pubmed:day	4
pubmed:volume	102
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	232-7
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:15623558-Animals, pubmed-meshheading:15623558-Hippocampus, pubmed-meshheading:15623558-Membrane Potentials, pubmed-meshheading:15623558-Mice, pubmed-meshheading:15623558-Receptors, Adrenergic, beta, pubmed-meshheading:15623558-Synapses, pubmed-meshheading:15623558-Time Factors
pubmed:year	2005
pubmed:articleTitle	Theta frequency stimulation up-regulates the synaptic strength of the pathway from CA1 to subiculum region of hippocampus.
pubmed:affiliation	Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't