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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-12-28
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pubmed:abstractText |
Cardiac energetics and performance depend on the expression level of the fast (alpha-) and slow (beta-) myosin heavy chain (MHC) isoform. In ventricular tissue, the beta-MHC isoform predominates, whereas in atrial tissue a variable mixture of alpha- and beta-MHC is found. In several cardiac diseases, the slow isoform is upregulated; however, the functional implications of this transition in human myocardium are largely unknown. The aim of this study was to determine the relation between contractile properties and MHC isoform composition in healthy human myocardium using the diversity in atrial tissue.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0008-6363
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pubmed:author |
pubmed-author:BoontjeN MNM,
pubmed-author:HuybregtsM A J MMA,
pubmed-author:NarolskaN ANA,
pubmed-author:PenasS EirasSE,
pubmed-author:RussellJJ,
pubmed-author:SpiegelenbergS RSR,
pubmed-author:StienenG J MGJ,
pubmed-author:VisserF CFC,
pubmed-author:ZarembaRR,
pubmed-author:de JongJ WJW,
pubmed-author:van LoonR BRB,
pubmed-author:van der VeldenJJ
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
221-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15621050-Adenosine Triphosphate,
pubmed-meshheading:15621050-Adult,
pubmed-meshheading:15621050-Aged,
pubmed-meshheading:15621050-Aged, 80 and over,
pubmed-meshheading:15621050-Atrial Function,
pubmed-meshheading:15621050-Biomechanics,
pubmed-meshheading:15621050-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:15621050-Heart Atria,
pubmed-meshheading:15621050-Heart Ventricles,
pubmed-meshheading:15621050-Humans,
pubmed-meshheading:15621050-Middle Aged,
pubmed-meshheading:15621050-Myocardial Contraction,
pubmed-meshheading:15621050-Myocardium,
pubmed-meshheading:15621050-Myosin Heavy Chains,
pubmed-meshheading:15621050-Protein Isoforms,
pubmed-meshheading:15621050-Ventricular Function
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pubmed:year |
2005
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pubmed:articleTitle |
Myocardial contraction is 5-fold more economical in ventricular than in atrial human tissue.
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pubmed:affiliation |
Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands. na.narolska@vumc.nl
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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