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pubmed:abstractText |
Erm, a member of the PEA3 group within the Ets family of transcription factors, is expressed in murine and human lymphocytes. Here, we show that in the human Molt4 lymphoblastic cell line, the erm gene expression is regulated by the conventional PKC (cPKC) pathway. To better characterize the molecular mechanism by which cPKC regulates Erm transcription in Molt4 cells, we tested proximal promoter deletions of the human gene, and identified a specific cPKC-regulated region between positions -420 and -115 upstream of the first exon.
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pubmed:affiliation |
Laboratoire de Virologie Moléculaire, Faculté de médecine, ULB, CP 614, 808 route de Lennik, 1070 Brussels, Belgium.
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