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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0031308,
umls-concept:C0037083,
umls-concept:C0851285,
umls-concept:C1424154,
umls-concept:C1424843,
umls-concept:C1424879,
umls-concept:C1510939,
umls-concept:C1516044,
umls-concept:C1709061,
umls-concept:C1710082
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pubmed:issue |
24
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pubmed:dateCreated |
2004-12-28
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pubmed:abstractText |
Phagocytosis of cells undergoing apoptosis is essential during development, cellular turnover, and wound healing. Failure to promptly clear apoptotic cells has been linked to autoimmune disorders. C. elegans CED-12 and mammalian ELMO are evolutionarily conserved scaffolding proteins that play a critical role in engulfment from worm to human. ELMO functions together with Dock180 (a guanine nucleotide exchange factor for Rac) to mediate Rac-dependent cytoskeletal reorganization during engulfment and cell migration. However, the components upstream of ELMO and Dock180 during engulfment remain elusive.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/CED-12 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DOCK1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ELMO1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/GTP Phosphohydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/Guanine Nucleotide Exchange Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Mig-2 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/RHOG protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TRIO protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/UNC-73 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/rac GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/rho GTP-Binding Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0960-9822
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pubmed:author |
pubmed-author:BlangyAnneA,
pubmed-author:ChengLi-ChunLC,
pubmed-author:ChouBin-KuanBK,
pubmed-author:GrimsleyCynthiaC,
pubmed-author:HaneyLisa BLB,
pubmed-author:HengartnerMichael OMO,
pubmed-author:HsuPei-KenPK,
pubmed-author:KinchenJason MJM,
pubmed-author:KlingeleDorisD,
pubmed-author:LuMingjianM,
pubmed-author:RavichandranKodi SKS,
pubmed-author:SondekJohnJ,
pubmed-author:WuYi-ChunYC,
pubmed-author:deBakkerColin DCD
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2208-16
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15620647-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:15620647-Animals,
pubmed-meshheading:15620647-Apoptosis,
pubmed-meshheading:15620647-Caenorhabditis elegans,
pubmed-meshheading:15620647-Caenorhabditis elegans Proteins,
pubmed-meshheading:15620647-Carrier Proteins,
pubmed-meshheading:15620647-Cytoskeletal Proteins,
pubmed-meshheading:15620647-Cytoskeleton,
pubmed-meshheading:15620647-GTP Phosphohydrolases,
pubmed-meshheading:15620647-Guanine Nucleotide Exchange Factors,
pubmed-meshheading:15620647-Humans,
pubmed-meshheading:15620647-Nerve Tissue Proteins,
pubmed-meshheading:15620647-Phagocytosis,
pubmed-meshheading:15620647-Phosphoproteins,
pubmed-meshheading:15620647-Protein-Serine-Threonine Kinases,
pubmed-meshheading:15620647-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:15620647-Signal Transduction,
pubmed-meshheading:15620647-rac GTP-Binding Proteins,
pubmed-meshheading:15620647-rho GTP-Binding Proteins
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pubmed:year |
2004
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pubmed:articleTitle |
Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO.
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pubmed:affiliation |
Department of Microbiology, Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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