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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-12-27
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pubmed:abstractText |
Several MC3T3-E1 cell-derived clones expressing higher levels of LH2b were analyzed for their abilities to form collagen fibrils and mineralization. The clones all exhibited smaller collagen fibrils and defective matrix mineralization in vitro and in vivo, indicating a critical role of LH2b-catalyzed post-translational modifications of collagen in bone matrix formation and mineralization.
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pubmed:grant |
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pubmed:keyword |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Fibrillar Collagens,
http://linkedlifedata.com/resource/pubmed/chemical/Ibsp protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Integrin-Binding Sialoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Osteocalcin,
http://linkedlifedata.com/resource/pubmed/chemical/Procollagen-Lysine, 2-Oxoglutarate...,
http://linkedlifedata.com/resource/pubmed/chemical/Sialoglycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/osterix protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0884-0431
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
81-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15619673-Animals,
pubmed-meshheading:15619673-Biological Markers,
pubmed-meshheading:15619673-Calcification, Physiologic,
pubmed-meshheading:15619673-Cells, Cultured,
pubmed-meshheading:15619673-Collagen Type I,
pubmed-meshheading:15619673-Fibrillar Collagens,
pubmed-meshheading:15619673-Gene Expression,
pubmed-meshheading:15619673-Integrin-Binding Sialoprotein,
pubmed-meshheading:15619673-Mice,
pubmed-meshheading:15619673-Neoplasm Proteins,
pubmed-meshheading:15619673-Osteoblasts,
pubmed-meshheading:15619673-Osteocalcin,
pubmed-meshheading:15619673-Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase,
pubmed-meshheading:15619673-Protein Processing, Post-Translational,
pubmed-meshheading:15619673-Sialoglycoproteins,
pubmed-meshheading:15619673-Transcription Factors,
pubmed-meshheading:15619673-Transcriptional Activation
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pubmed:year |
2005
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pubmed:articleTitle |
Overexpression of lysyl hydroxylase-2b leads to defective collagen fibrillogenesis and matrix mineralization.
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pubmed:affiliation |
Dental Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7455, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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