| pubmed-article:15618968 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15618968 | lifeskim:mentions | umls-concept:C0022567 | lld:lifeskim |
| pubmed-article:15618968 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:15618968 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:15618968 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15618968 | pubmed:dateCreated | 2005-2-15 | lld:pubmed |
| pubmed-article:15618968 | pubmed:abstractText | Keratinocyte apoptosis induced by UV radiation is a major protective mechanism from skin photocarcinogenesis. The induction of apoptosis by UV radiation, as well as a variety of genotoxic stimuli, involves the activation of PKC-delta by caspase-3-mediated cleavage in its hinge region, thus generating a constitutively active catalytic fragment. To determine the role of PKC-delta cleavage in UV apoptosis signaling, we introduced a caspase-resistant PKC-delta mutant (D330A) into human keratinocytes by retrovirus transduction. Overexpression of PKC-delta(D330A) protected keratinocytes from UV-induced apoptosis and enhanced long-term survival. PKC-delta(D330A) partially prevented the release of cytochrome c from the mitochondria and the loss of Mcl-1, a key antiapoptotic protein downregulated during UV apoptosis. Thus, the cleavage and activation of PKC-delta are critical components of UV-induced apoptosis in human keratinocytes, and the inactivation of PKC-delta can promote the survival of keratinocytes exposed to UV radiation. | lld:pubmed |
| pubmed-article:15618968 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15618968 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15618968 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15618968 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15618968 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15618968 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15618968 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15618968 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15618968 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15618968 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15618968 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15618968 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15618968 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15618968 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15618968 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15618968 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15618968 | pubmed:issn | 1350-9047 | lld:pubmed |
| pubmed-article:15618968 | pubmed:author | pubmed-author:DenningM FMF | lld:pubmed |
| pubmed-article:15618968 | pubmed:author | pubmed-author:D'CostaA MAM | lld:pubmed |
| pubmed-article:15618968 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15618968 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:15618968 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15618968 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15618968 | pubmed:pagination | 224-32 | lld:pubmed |
| pubmed-article:15618968 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:15618968 | pubmed:meshHeading | pubmed-meshheading:15618968... | lld:pubmed |
| pubmed-article:15618968 | pubmed:meshHeading | pubmed-meshheading:15618968... | lld:pubmed |
| pubmed-article:15618968 | pubmed:meshHeading | pubmed-meshheading:15618968... | lld:pubmed |
| pubmed-article:15618968 | pubmed:meshHeading | pubmed-meshheading:15618968... | lld:pubmed |
| pubmed-article:15618968 | pubmed:meshHeading | pubmed-meshheading:15618968... | lld:pubmed |
| pubmed-article:15618968 | pubmed:meshHeading | pubmed-meshheading:15618968... | lld:pubmed |
| pubmed-article:15618968 | pubmed:meshHeading | pubmed-meshheading:15618968... | lld:pubmed |
| pubmed-article:15618968 | pubmed:meshHeading | pubmed-meshheading:15618968... | lld:pubmed |
| pubmed-article:15618968 | pubmed:meshHeading | pubmed-meshheading:15618968... | lld:pubmed |
| pubmed-article:15618968 | pubmed:meshHeading | pubmed-meshheading:15618968... | lld:pubmed |
| pubmed-article:15618968 | pubmed:meshHeading | pubmed-meshheading:15618968... | lld:pubmed |
| pubmed-article:15618968 | pubmed:meshHeading | pubmed-meshheading:15618968... | lld:pubmed |
| pubmed-article:15618968 | pubmed:meshHeading | pubmed-meshheading:15618968... | lld:pubmed |
| pubmed-article:15618968 | pubmed:meshHeading | pubmed-meshheading:15618968... | lld:pubmed |
| pubmed-article:15618968 | pubmed:meshHeading | pubmed-meshheading:15618968... | lld:pubmed |
| pubmed-article:15618968 | pubmed:meshHeading | pubmed-meshheading:15618968... | lld:pubmed |
| pubmed-article:15618968 | pubmed:meshHeading | pubmed-meshheading:15618968... | lld:pubmed |
| pubmed-article:15618968 | pubmed:meshHeading | pubmed-meshheading:15618968... | lld:pubmed |
| pubmed-article:15618968 | pubmed:meshHeading | pubmed-meshheading:15618968... | lld:pubmed |
| pubmed-article:15618968 | pubmed:meshHeading | pubmed-meshheading:15618968... | lld:pubmed |
| pubmed-article:15618968 | pubmed:meshHeading | pubmed-meshheading:15618968... | lld:pubmed |
| pubmed-article:15618968 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15618968 | pubmed:articleTitle | A caspase-resistant mutant of PKC-delta protects keratinocytes from UV-induced apoptosis. | lld:pubmed |
| pubmed-article:15618968 | pubmed:affiliation | Division of Molecular and Cellular Biochemistry, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL 60153, USA. | lld:pubmed |
| pubmed-article:15618968 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15618968 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15618968 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:5580 | entrezgene:pubmed | pubmed-article:15618968 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15618968 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15618968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15618968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15618968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15618968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15618968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15618968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15618968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15618968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15618968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15618968 | lld:pubmed |
