Source:http://linkedlifedata.com/resource/pubmed/id/15618892
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2004-12-24
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pubmed:abstractText |
Environmental enrichment enhances learning and memory in both rodents and man. We examined the effect of active manipulation of a novel object (toy) on cognitive performance and acetylcholine (ACh) efflux in the hippocampus of rats. Animals exposed to the toy showed a significant increase in hippocampal ACh efflux provided that they actively manipulated the object. Similarly, a single 1 h introduction of the novel object (toy) immediately after a training session in a radial arm maze significantly improved memory only if the animals actively manipulated the object. The data suggest that environmental enrichment during a critical period (consolidation) is sufficient to improve learning and memory. This effect is likely mediated through an enhancement of hippocampal cholinergic neurotransmission.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0959-4965
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
63-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15618892-Acetylcholine,
pubmed-meshheading:15618892-Animals,
pubmed-meshheading:15618892-Cognition,
pubmed-meshheading:15618892-Hippocampus,
pubmed-meshheading:15618892-Learning,
pubmed-meshheading:15618892-Male,
pubmed-meshheading:15618892-Maze Learning,
pubmed-meshheading:15618892-Memory,
pubmed-meshheading:15618892-Microdialysis,
pubmed-meshheading:15618892-Rats,
pubmed-meshheading:15618892-Rats, Wistar,
pubmed-meshheading:15618892-Touch
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pubmed:year |
2005
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pubmed:articleTitle |
Acute exposure to a novel object during consolidation enhances cognition.
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pubmed:affiliation |
Eli Lilly and Company, Lilly Corporate Center, Neuroscience Discovery Research, Indianapolis, IN 46285-0510, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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