Source:http://linkedlifedata.com/resource/pubmed/id/15618702
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2004-12-27
|
| pubmed:abstractText |
Three novel single nucleotide polymorphisms (SNPs) were found in the UDP-glucuronosyltransferase (UGT) 1A10 gene from 24 Japanese patients with various cancers who were administered the anti-tumor drug, irinotecan (CPT-11). The detected SNPs were as follows: 1) SNP, MPJ6_U1A003; GENE NAME, UGT1A10; ACCESSION NUMBER, AF297093; LENGTH, 25 bases; 5'-CAGATGCCATGAC/TTTTCAAGGAGAG-3'. 2) SNP, MPJ6_U1A004; GENE NAME, UGT1A10; ACCESSION NUMBER, AF297093; LENGTH, 25 bases; 5'-CCTAGAAATAGCC/TTCTGAAATTCTC-3'. 3) SNP, MPJ6_U1A030; GENE NAME, UGT1A10; ACCESSION NUMBER, AF297093; LENGTH, 25 bases; 5'-GGTTGTAGTCATG/ACCAGAGGTGAGT-3' All the three SNPs were located in exon 1 and their frequencies were all 0.021. Among these SNPs, MPJ6_U1A003 and U1A030 resulted in amino acid alterations, T202I and M59I, respectively. The third SNP, MPJ6_U1A004, introduced a synonymous amino acid change (A231A).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
|
| pubmed:issn |
1347-4367
|
| pubmed:author |
pubmed-author:GotoKoichiK,
pubmed-author:HamaguchiTetsuyaT,
pubmed-author:JinnoHidetoH,
pubmed-author:KakinumaRyutaroR,
pubmed-author:KubotaKaoruK,
pubmed-author:KunitohHideoH,
pubmed-author:MeraKiyomiK,
pubmed-author:MinamiHironobuH,
pubmed-author:MutoManabuM,
pubmed-author:NihoSeijiS,
pubmed-author:NokiharaHiroshiH,
pubmed-author:OheYuichiroY,
pubmed-author:OhmatsuHironobuH,
pubmed-author:OhtsuAtsushiA,
pubmed-author:OzawaShogoS,
pubmed-author:SaekiMayumiM,
pubmed-author:SaijoNagahiroN,
pubmed-author:SaitoYoshiroY,
pubmed-author:SawadaJun-ichiJ,
pubmed-author:ShimadaYasuhiroY,
pubmed-author:ShiraoKuniakiK,
pubmed-author:YamadaYasuhideY,
pubmed-author:YamamotoNoboruN,
pubmed-author:YoshidaTeruhikoT
|
| pubmed:issnType |
Print
|
| pubmed:volume |
17
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
488-90
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Three novel single nucleotide polymorphisms in UGT1A10.
|
| pubmed:affiliation |
Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan.
|
| pubmed:publicationType |
Journal Article
|