Linked Life Data

15618618

Source:http://linkedlifedata.com/resource/pubmed/id/15618618

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2004-12-24
pubmed:abstractText
This study investigates the phosphorus (P) homeostasis in the process of an altered parathyroid hormone (PTH) action in the kidney of rats fed a high P diet. Four-week-old male Wistar strain rats were fed diets containing five different P levels (0.3, 0.6, 0.9, 1.2 and 1.5%) for 21 days. The serum PTH concentration and urinary excretion of P were elevated with increasing dietary P level. Compared to rats fed the 0.3% P diet, the serum calcium (Ca) concentration remained unchanged, while the serum 1,25(OH)(2)D(3) concentration and urinary excretion of cAMP were elevated with increasing dietary P level in rats fed the high P diets containing 0.6-0.9% P. On the other hand, a lower serum Ca concentration was observed in rats fed the high P diets containing 1.2% or greater P. The serum 1,25(OH)(2)D(3) concentration remained unchanged in rats fed the high P diets containing 1.2% or greater P, comparison with rats fed the 0.3% P diet. The urinary excretion of cAMP and PTH/PTH-related peptide (PTHrP) receptor and type II sodium-dependent phosphate transporter (NaPi-2) mRNA in the kidney were both decreased in rats fed the high P diets containing 1.2% or greater P. In conclusion, a high P diet with subsequent decrease in serum Ca concentration suppressed the PTH action in the kidney due to PTH/PTHrP receptor mRNA down-regulation. Furthermore, an increase in the urinary excretion of P might have been caused by decreased NaPi-2 mRNA expression without the effects of PTH and 1,25(OH)(2)D(3).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0916-8451
pubmed:author
pubmed:issnType
Print
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2484-9
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed-meshheading:15618618-Animals, pubmed-meshheading:15618618-Calcium, pubmed-meshheading:15618618-Cyclic AMP, pubmed-meshheading:15618618-Diet, pubmed-meshheading:15618618-Dose-Response Relationship, Drug, pubmed-meshheading:15618618-Gene Expression Regulation, pubmed-meshheading:15618618-Homeostasis, pubmed-meshheading:15618618-Kidney, pubmed-meshheading:15618618-Male, pubmed-meshheading:15618618-Parathyroid Hormone, pubmed-meshheading:15618618-Phosphorus, pubmed-meshheading:15618618-RNA, Messenger, pubmed-meshheading:15618618-Rats, pubmed-meshheading:15618618-Rats, Wistar, pubmed-meshheading:15618618-Receptor, Parathyroid Hormone, Type 1, pubmed-meshheading:15618618-Sodium-Phosphate Cotransporter Proteins, pubmed-meshheading:15618618-Sodium-Phosphate Cotransporter Proteins, Type II, pubmed-meshheading:15618618-Symporters
pubmed:year
2004
pubmed:articleTitle
Decreased mRNA expression of the PTH/PTHrP receptor and type II sodium-dependent phosphate transporter in the kidney of rats fed a high phosphorus diet accompanied with a decrease in serum calcium concentration.
pubmed:affiliation
Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.
pubmed:publicationType
Journal Article