pubmed:abstractText |
Probimane (Pro), an anti-cancer agent originating in China, was derived from razoxane (ICRF-159, Raz), a drug created in Britain, specifically targeting at cancer metastasis and as a cardioprotectant of anthrocyclines. Pro and Raz are bisdioxopiperazine compounds. In this work, we evaluated the anti-tumor and anti-metastatic effects of Pro and Raz in vivo against two lung tumor models, one of murine origin (Lewis lung carcinoma, LLC) and one of human origin (LAX-83).
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pubmed:affiliation |
Division of Anticancer Pharmacology, Shanghai Institute of Materia Medica, Shanghai Institutes of Biology Sciences, Chinese Academy of Sciences, Shanghai 201203, PR China. ludayong@sh163.net
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