Linked Life Data

15616083

Source:http://linkedlifedata.com/resource/pubmed/id/15616083

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-12-23
pubmed:abstractText
In a double-blind, randomized, controlled clinical trial, we compared the analgesic effect of remifentanil in patient-controlled IV analgesia (PCIA) during labor and delivery with the effect of an IV infusion of meperidine. Eighty-eight healthy term parturients who requested IV analgesia for labor pain were enrolled in the study and were randomly assigned to receive either increasing doses (0.27-0.93 microg/kg per bolus) of PCIA remifentanil (n=43) or an IV infusion of meperidine 150 mg (range, 75-200 mg) per patient (n=45). Remifentanil by the PCIA device was more effective and reliable analgesia for labor and delivery than IV infusion of meperidine. The visual analog score was lower (35.8 +/- 10.2 versus 58.8 +/- 12.8; P <0.001) and the patient satisfaction score higher (3.9 +/- 0.6 versus 1.9 +/- 0.4; P <0.001), with less of a sedative effect (1.2 +/- 0.1 versus 2.9 +/- 0.1; P <0.001) and less hemoglobin desaturation (97.5% +/- 1.0 versus 94.2% +/- 1.5; P <0.007). The percentage of analgesia failure (the rate of crossover from opiate to epidural analgesia) was less for remifentanil compared with meperidine (10.8% versus 38.8%; P <0.007). There were no significant differences between groups in the mode of delivery or neonatal outcome. There were fewer nonreassuring abnormal fetal heart rate patterns, i.e., higher variability and reactivity with fewer decelerations, under remifentanil therapy as compared with meperidine (P <0.001). In conclusion, an intermittent incremental regimen with repeated small-dose PCIA boluses of remifentanil provided effective and reliable analgesia during labor and delivery.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0003-2999
pubmed:author
pubmed:issnType
Print
pubmed:volume
100
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
233-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Remifentanil: a novel systemic analgesic for labor pain.
pubmed:affiliation
Department of Anesthesia, Wolfson Medical Center, Holon, Israel.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial