|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0000768,
umls-concept:C0021289,
umls-concept:C0022646,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0151650,
umls-concept:C0458003,
umls-concept:C0678226,
umls-concept:C0678723,
umls-concept:C1517945,
umls-concept:C1855283
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|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2005-1-27
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|
pubmed:abstractText |
A disintegrin and metalloproteinase with thrombospondin motifs 1, Adamts-1, is important for the development and function of the kidney. Mice lacking this protein present with renal lesions comprising enlarged calyces, and reduced cortex and medulla layers. Our current findings are consistent with the defect occurring due to a developmental dysgenesis.
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|
pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
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pubmed:issn |
0931-0509
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
20
|
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
419-23
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15615810-ADAM Proteins,
pubmed-meshheading:15615810-Aging,
pubmed-meshheading:15615810-Animals,
pubmed-meshheading:15615810-Animals, Newborn,
pubmed-meshheading:15615810-Codon, Terminator,
pubmed-meshheading:15615810-Crosses, Genetic,
pubmed-meshheading:15615810-Disintegrins,
pubmed-meshheading:15615810-Female,
pubmed-meshheading:15615810-Frameshift Mutation,
pubmed-meshheading:15615810-In Situ Hybridization,
pubmed-meshheading:15615810-Kidney,
pubmed-meshheading:15615810-Kidney Diseases,
pubmed-meshheading:15615810-Kidney Medulla,
pubmed-meshheading:15615810-Male,
pubmed-meshheading:15615810-Metalloendopeptidases,
pubmed-meshheading:15615810-Mice,
pubmed-meshheading:15615810-Mice, Inbred C57BL,
pubmed-meshheading:15615810-Mice, Knockout,
pubmed-meshheading:15615810-Models, Animal
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|
pubmed:year |
2005
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|
pubmed:articleTitle |
Neonatal calyceal dilation and renal fibrosis resulting from loss of Adamts-1 in mouse kidney is due to a developmental dysgenesis.
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|
pubmed:affiliation |
Monash Institute of Reproduction and Development, Monash University, Clayton 3168, Victoria, Australia.
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pubmed:publicationType |
Journal Article
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