| pubmed-article:15613615 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15613615 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:15613615 | lifeskim:mentions | umls-concept:C1704242 | lld:lifeskim |
| pubmed-article:15613615 | lifeskim:mentions | umls-concept:C1160577 | lld:lifeskim |
| pubmed-article:15613615 | lifeskim:mentions | umls-concept:C1948027 | lld:lifeskim |
| pubmed-article:15613615 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:15613615 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15613615 | pubmed:dateCreated | 2005-3-22 | lld:pubmed |
| pubmed-article:15613615 | pubmed:abstractText | Genomic microarray analysis of genes specifically expressed in a pure cell isolate from a heterocellular organ identified the likely K efflux channel associated with the gastric H-K-ATPase. The function of this channel is to supply K to the luminal surface of the pump to allow H for K exchange. KCNQ1-KCNE2 was the most highly expressed and significantly enriched member of the large variety of K channels expressed in the gastric epithelium. The function of this K channel in acid secretion was then shown by inhibition of secretion in isolated gastric glands with specific KCNQ inhibitors and by colocalization of the channel with the H-K-ATPase in the secretory canaliculus of the parietal cell. KCNQ1-KCNE2 appears to be the K efflux channel that is essential for gastric acid secretion. | lld:pubmed |
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| pubmed-article:15613615 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15613615 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15613615 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15613615 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15613615 | pubmed:issn | 1531-2267 | lld:pubmed |
| pubmed-article:15613615 | pubmed:author | pubmed-author:ScottDavidD | lld:pubmed |
| pubmed-article:15613615 | pubmed:author | pubmed-author:SachsGeorgeG | lld:pubmed |
| pubmed-article:15613615 | pubmed:author | pubmed-author:LambrechtNils... | lld:pubmed |
| pubmed-article:15613615 | pubmed:author | pubmed-author:YakubovIskand... | lld:pubmed |
| pubmed-article:15613615 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:15613615 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:15613615 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:15613615 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15613615 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15613615 | pubmed:pagination | 81-91 | lld:pubmed |
| pubmed-article:15613615 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:15613615 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15613615 | pubmed:articleTitle | Identification of the K efflux channel coupled to the gastric H-K-ATPase during acid secretion. | lld:pubmed |
| pubmed-article:15613615 | pubmed:affiliation | Department of Pathology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA. nilslam@ucla.edu | lld:pubmed |
| pubmed-article:15613615 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15613615 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15613615 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:15613615 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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