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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-3-22
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pubmed:abstractText |
Genomic microarray analysis of genes specifically expressed in a pure cell isolate from a heterocellular organ identified the likely K efflux channel associated with the gastric H-K-ATPase. The function of this channel is to supply K to the luminal surface of the pump to allow H for K exchange. KCNQ1-KCNE2 was the most highly expressed and significantly enriched member of the large variety of K channels expressed in the gastric epithelium. The function of this K channel in acid secretion was then shown by inhibition of secretion in isolated gastric glands with specific KCNQ inhibitors and by colocalization of the channel with the H-K-ATPase in the secretory canaliculus of the parietal cell. KCNQ1-KCNE2 appears to be the K efflux channel that is essential for gastric acid secretion.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acridine Orange,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Aminopyrine,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/KCNE2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/KCNQ1 Potassium Channel,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, Voltage-Gated,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1531-2267
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
21
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
81-91
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15613615-Acridine Orange,
pubmed-meshheading:15613615-Adenosine Triphosphatases,
pubmed-meshheading:15613615-Aminopyrine,
pubmed-meshheading:15613615-Animals,
pubmed-meshheading:15613615-Cell Separation,
pubmed-meshheading:15613615-DNA Primers,
pubmed-meshheading:15613615-Dose-Response Relationship, Drug,
pubmed-meshheading:15613615-Epithelium,
pubmed-meshheading:15613615-Flow Cytometry,
pubmed-meshheading:15613615-Gastric Acid,
pubmed-meshheading:15613615-Gastric Mucosa,
pubmed-meshheading:15613615-Immunohistochemistry,
pubmed-meshheading:15613615-KCNQ1 Potassium Channel,
pubmed-meshheading:15613615-Male,
pubmed-meshheading:15613615-Microscopy, Confocal,
pubmed-meshheading:15613615-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:15613615-Oligonucleotides,
pubmed-meshheading:15613615-Potassium,
pubmed-meshheading:15613615-Potassium Channels,
pubmed-meshheading:15613615-Potassium Channels, Voltage-Gated,
pubmed-meshheading:15613615-RNA, Complementary,
pubmed-meshheading:15613615-RNA, Messenger,
pubmed-meshheading:15613615-Rabbits,
pubmed-meshheading:15613615-Rats,
pubmed-meshheading:15613615-Rats, Sprague-Dawley,
pubmed-meshheading:15613615-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15613615-Stomach
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pubmed:year |
2005
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pubmed:articleTitle |
Identification of the K efflux channel coupled to the gastric H-K-ATPase during acid secretion.
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pubmed:affiliation |
Department of Pathology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA. nilslam@ucla.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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