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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0024420,
umls-concept:C0033572,
umls-concept:C0086418,
umls-concept:C0138741,
umls-concept:C0242210,
umls-concept:C0927195,
umls-concept:C1171362,
umls-concept:C1366489,
umls-concept:C1417779,
umls-concept:C1515670,
umls-concept:C2003941
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pubmed:issue |
3
|
|
pubmed:dateCreated |
2005-3-30
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|
pubmed:abstractText |
Benign prostatic hyperplasia (BPH) is characterized as a stromal process. The stroma smooth muscle (SM) may alter its phenotype during the progression of BPH. We have identified gene transcripts that may be differentially expressed in BPH using a differential display method. Among the fragments isolated, alpha(2) macroglobulin (alpha(2)-M) is one of the most interesting. alpha(2)-M is a binding protein of a variety of proteinases, including prostatic specific antigen (PSA). It also plays roles in molecular trapping and targeting. In this study, we characterized alpha(2)-M expression in the human prostate.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0270-4137
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2004 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
63
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
299-308
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pubmed:meshHeading |
pubmed-meshheading:15611997-Blotting, Western,
pubmed-meshheading:15611997-Cells, Cultured,
pubmed-meshheading:15611997-Culture Media, Conditioned,
pubmed-meshheading:15611997-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:15611997-Gene Expression,
pubmed-meshheading:15611997-Gene Expression Profiling,
pubmed-meshheading:15611997-Humans,
pubmed-meshheading:15611997-Immunohistochemistry,
pubmed-meshheading:15611997-In Situ Hybridization,
pubmed-meshheading:15611997-Male,
pubmed-meshheading:15611997-Prostate,
pubmed-meshheading:15611997-Prostatic Hyperplasia,
pubmed-meshheading:15611997-RNA, Messenger,
pubmed-meshheading:15611997-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15611997-Stromal Cells,
pubmed-meshheading:15611997-Tissue Culture Techniques,
pubmed-meshheading:15611997-alpha-Macroglobulins
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pubmed:year |
2005
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pubmed:articleTitle |
Alpha(2) macroglobulin, a PSA binding protein, is expressed in human prostate stroma.
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pubmed:affiliation |
Department of Urology, The University of Texas, Southwestern Medical Center, Dallas, Texas, USA. victor.lin@utsouthwestern.edu
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pubmed:publicationType |
Journal Article
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