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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-12-23
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pubmed:abstractText |
A case of a leukemic transformation following a 27-year history of idiopathic myelofibrosis (IMF) is presented. The patient had two chromosomal abnormalities: a deletion of chromosome 13, del 13(q12q14), and a deletion of chromosome 11, del 11(q14q23). This patient's final diagnosis was acute micromegakaryocytic leukemia, and she died 1 month after leukemic transformation with an additional chromosomal abnormality, trisomy 8. IMF with myeloid metaplasia associated with deletion of the long arms of chromosomes 11 and 13 has not been previously reported. We speculate that the leukemic transformation in this patient was associated with chromosomal abnormalities del 11 and trisomy 8.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0361-8609
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pubmed:author |
pubmed-author:AsakaMasahiroM,
pubmed-author:HigaToshioT,
pubmed-author:IbataMakotoM,
pubmed-author:ImamuraMasahiroM,
pubmed-author:KahataKaoruK,
pubmed-author:KasaiMasaharuM,
pubmed-author:MashikoShinobuS,
pubmed-author:MiuraYokoY,
pubmed-author:MoriokaMasanobuM,
pubmed-author:OtaShuichiS,
pubmed-author:ShonoYusukeY,
pubmed-author:TanakaJunjiJ,
pubmed-author:ToubaiTomomiT,
pubmed-author:ToyoshimaNobuyasuN,
pubmed-author:UmeharaShintaroS
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pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
67-70
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15609290-Bone Marrow,
pubmed-meshheading:15609290-Chromosome Aberrations,
pubmed-meshheading:15609290-Chromosomes, Human, Pair 11,
pubmed-meshheading:15609290-Chromosomes, Human, Pair 13,
pubmed-meshheading:15609290-Chromosomes, Human, Pair 8,
pubmed-meshheading:15609290-Fatal Outcome,
pubmed-meshheading:15609290-Female,
pubmed-meshheading:15609290-Follow-Up Studies,
pubmed-meshheading:15609290-Gene Deletion,
pubmed-meshheading:15609290-Humans,
pubmed-meshheading:15609290-Leukemia, Megakaryoblastic, Acute,
pubmed-meshheading:15609290-Middle Aged,
pubmed-meshheading:15609290-Primary Myelofibrosis,
pubmed-meshheading:15609290-Trisomy
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pubmed:year |
2005
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pubmed:articleTitle |
Long-term follow-up of a patient with idiopathic myelofibrosis associated with chromosome 11 and 13 abnormalities.
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pubmed:affiliation |
Department of Hematology and Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. ttoubai@hkg.odn.ne.jp
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pubmed:publicationType |
Journal Article,
Case Reports
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