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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2004-12-20
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pubmed:abstractText |
Recent research has implicated the endogenous opioid system in the development of alcohol use disorders. The A118G polymorphism of the OPRM1 gene has been shown to confer functional differences to mu-opioid receptors, such that the G variant binds beta-endorphin three times more strongly than the A variant. The goal of this study was to test whether the A118G polymorphism is associated with sensitivity to the effects of alcohol.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0145-6008
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1789-95
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15608594-Adult,
pubmed-meshheading:15608594-Affect,
pubmed-meshheading:15608594-Alcohol Drinking,
pubmed-meshheading:15608594-Alleles,
pubmed-meshheading:15608594-Breath Tests,
pubmed-meshheading:15608594-Chi-Square Distribution,
pubmed-meshheading:15608594-Ethanol,
pubmed-meshheading:15608594-Female,
pubmed-meshheading:15608594-Humans,
pubmed-meshheading:15608594-Infusions, Intravenous,
pubmed-meshheading:15608594-Male,
pubmed-meshheading:15608594-Polymorphism, Genetic,
pubmed-meshheading:15608594-Receptors, Opioid, mu
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pubmed:year |
2004
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pubmed:articleTitle |
A polymorphism of the mu-opioid receptor gene (OPRM1) and sensitivity to the effects of alcohol in humans.
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pubmed:affiliation |
University of Colorado, Boulder, CO 80309-0345, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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