Linked Life Data

15607956

Source:http://linkedlifedata.com/resource/pubmed/id/15607956

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2004-12-20
pubmed:abstractText
Leukemia stem cells are defined as transformed hematopoietic stem cells or committed progenitor cells that have amplified or acquired the stem cell capacity for self-renewal, albeit in a poorly regulated fashion. In this issue of Cancer Cell, Huntly and colleagues report a striking difference in the ability of two leukemia-associated fusion proteins, MOZ-TIF2 and BCR-ABL, to transform myeloid progenitor populations. This rigorous study supports the idea of a hierarchy among leukemia-associated protooncogenes for their ability to endow committed myeloid progenitors with the self-renewal capacity driving leukemic stem cell propagation, and sheds new light on the pathogenesis of chronic and acute myelogenous leukemias.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1535-6108
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
531-3
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:15607956-Acute Disease, pubmed-meshheading:15607956-Cell Differentiation, pubmed-meshheading:15607956-Cell Transformation, Neoplastic, pubmed-meshheading:15607956-Cytoskeletal Proteins, pubmed-meshheading:15607956-Fusion Proteins, bcr-abl, pubmed-meshheading:15607956-Hematopoietic Stem Cells, pubmed-meshheading:15607956-Humans, pubmed-meshheading:15607956-Leukemia, Myelogenous, Chronic, BCR-ABL Positive, pubmed-meshheading:15607956-Leukemia, Myeloid, pubmed-meshheading:15607956-Models, Biological, pubmed-meshheading:15607956-Myeloid Progenitor Cells, pubmed-meshheading:15607956-Myeloid-Lymphoid Leukemia Protein, pubmed-meshheading:15607956-Neoplastic Stem Cells, pubmed-meshheading:15607956-Oncogene Proteins, Fusion, pubmed-meshheading:15607956-Proto-Oncogenes, pubmed-meshheading:15607956-Trans-Activators, pubmed-meshheading:15607956-beta Catenin
pubmed:year
2004
pubmed:articleTitle
Chronic versus acute myelogenous leukemia: a question of self-renewal.
pubmed:affiliation
Institute of Cancer and Stem Cell Biology and Medicine, Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
pubmed:publicationType
Journal Article, Comparative Study, Comment