| pubmed-article:15607822 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15607822 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:15607822 | lifeskim:mentions | umls-concept:C0039215 | lld:lifeskim |
| pubmed-article:15607822 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:15607822 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:15607822 | pubmed:dateCreated | 2004-12-20 | lld:pubmed |
| pubmed-article:15607822 | pubmed:abstractText | The transcription factor LKLF (lung Krüppel-like factor) is expressed at high levels in quiescent CD4+ and CD8+ T lymphocytes and provides an important role in establishment and maintenance of the quiescent state. To identify LKLF-regulated genes, we performed microarray analysis using an established Jurkat T cell line containing a tetracycline-inducible LKLF. LKLF induction in this Jurkat T cell line generates a quiescent phenotype that resembles memory CD4+ T lymphocytes. We found that LKLF induction in Jurkat cells resulted in up-regulation (>1.5-fold) of about 100 mRNAs, while it repressed (>1.5-fold) a similar number of mRNAs. A striking feature of the LKLF-stimulated mRNAs was that a significant number of them encode cell surface proteins or proteins implicated in initiating and propagating cellular signaling cascades. The data suggests that LKLF may establish a phenotype that primes quiescent cells for responses to specific extracellular stimuli. The mRNAs encoding CDw52, IL-10R alpha and paxillin were among the most highly induced transcripts in Jurkat T cells, and we observed that the encoded proteins are down-regulated following activation of quiescent CD4+ T cells isolated from healthy blood donors. We also examined whether LKLF-induced quiescence in Jurkat cells could silence transcription of integrated HIV-1 proviruses. We found however that LKLF-induced quiescence is not sufficient to repress expression of HIV-1 proviruses in Jurkat T cells, suggesting that the HIV-1 provirus is resistant to LKLF-regulated quiescence. | lld:pubmed |
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| pubmed-article:15607822 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15607822 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15607822 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15607822 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15607822 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15607822 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15607822 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15607822 | pubmed:issn | 0161-5890 | lld:pubmed |
| pubmed-article:15607822 | pubmed:author | pubmed-author:RiceAndrew... | lld:pubmed |
| pubmed-article:15607822 | pubmed:author | pubmed-author:YuWendongW | lld:pubmed |
| pubmed-article:15607822 | pubmed:author | pubmed-author:HaalandRichar... | lld:pubmed |
| pubmed-article:15607822 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15607822 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:15607822 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15607822 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15607822 | pubmed:pagination | 627-41 | lld:pubmed |
| pubmed-article:15607822 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:15607822 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15607822 | pubmed:articleTitle | Identification of LKLF-regulated genes in quiescent CD4+ T lymphocytes. | lld:pubmed |
| pubmed-article:15607822 | pubmed:affiliation | Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. | lld:pubmed |
| pubmed-article:15607822 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15607822 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:15607822 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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