Source:http://linkedlifedata.com/resource/pubmed/id/15607601
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2004-12-20
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| pubmed:abstractText |
Acute and disseminated demyelination of the central nervous system in children may have many causes. This study reports a retrospective cohort of 10 consecutive pediatric cases (5 to 17 years; mean [S.D.] 12.1 [4.3] years) with a presenting diagnosis of acute disseminated encephalomyelitis and the clinical and radiologic follow-up. The evolution of magnetic resonance imaging abnormalities was determined from serial studies in nine patients with a mean (S.D.) follow-up of 334.2 (312.8) days. Resolution of magnetic resonance imaging T(2) prolongation (i.e., demyelination) within 6 months of presentation was associated most commonly with a final clinical diagnosis of acute disseminated encephalomyelitis (including the multiphasic form), but failed to meet statistical significance (Fisher's exact test; P = 0.083). Incomplete resolution of the magnetic resonance imaging signal abnormalities yielded a statistically significant association (Fisher's exact test; P = 0.048) with an abnormal neurologic outcome. In summary, we conclude that early resolution of magnetic resonance imaging signal abnormalities or recurrent demyelination within 6 months of an acute and disseminated demyelinating event suggests the diagnosis of acute disseminated encephalomyelitis in children, although this association failed to meet statistical significance. However, a statistically significant association between complete resolution of magnetic resonance imaging signal abnormalities and a normal neurologic outcome was observed.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0887-8994
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
32
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
30-6
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| pubmed:dateRevised |
2006-5-23
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| pubmed:meshHeading |
pubmed-meshheading:15607601-Adolescent,
pubmed-meshheading:15607601-Central Nervous System,
pubmed-meshheading:15607601-Child,
pubmed-meshheading:15607601-Child, Preschool,
pubmed-meshheading:15607601-Encephalomyelitis, Acute Disseminated,
pubmed-meshheading:15607601-Female,
pubmed-meshheading:15607601-Follow-Up Studies,
pubmed-meshheading:15607601-Humans,
pubmed-meshheading:15607601-Magnetic Resonance Imaging,
pubmed-meshheading:15607601-Male
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| pubmed:year |
2005
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| pubmed:articleTitle |
Neuroimaging features of acute disseminated encephalomyelitis in childhood.
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| pubmed:affiliation |
Division of Neurology, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
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| pubmed:publicationType |
Journal Article
|