| pubmed-article:15606801 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15606801 | lifeskim:mentions | umls-concept:C0029347 | lld:lifeskim |
| pubmed-article:15606801 | lifeskim:mentions | umls-concept:C0521026 | lld:lifeskim |
| pubmed-article:15606801 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:15606801 | lifeskim:mentions | umls-concept:C0383327 | lld:lifeskim |
| pubmed-article:15606801 | lifeskim:mentions | umls-concept:C0876973 | lld:lifeskim |
| pubmed-article:15606801 | lifeskim:mentions | umls-concept:C0449297 | lld:lifeskim |
| pubmed-article:15606801 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:15606801 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15606801 | pubmed:dateCreated | 2004-12-20 | lld:pubmed |
| pubmed-article:15606801 | pubmed:abstractText | T helper 1 driven immune responses facilitate host defence during viral infections. Because interleukin-18 (IL-18) mediates T helper 1 driven immune responses, and since mature IL-18 is up-regulated in human macrophages after influenza virus infection in vitro, it has been suggested that IL-18 plays an important role in the immune response to influenza. To determine the role of IL-18 in respiratory tract infection with influenza, IL-18 gene-deficient (IL-18(-/-)) and normal wildtype mice were intranasally inoculated with influenza A virus. Influenza resulted in an increase in constitutively expressed IL-18 in the lungs of wildtype mice. The clearance of influenza A was inhibited by IL-18, as indicated by reduced viral loads on day 8 and day 12 after infection in IL-18(-/-) mice. This enhanced viral clearance correlated with increased CD4(+) T-cell activation in the lungs as reflected by CD69 expression on the cell surface. Surprisingly, interferon-gamma (IFN-gamma) levels were similar in the lungs of IL-18(-/-) mice and wildtype mice. Intracellular IFN-gamma staining revealed similar expression levels in lung-derived natural killer cells, CD4(+) and CD8(+) T cells, indicating that IFN-gamma production is IL-18-independent during influenza virus infection. Tumour necrosis factor-alpha production by CD4(+) T cells was significantly lower in IL-18(-/-) mice than in wildtype mice. Our data indicate that endogenous IL-18 impairs viral clearance during influenza A infection. | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15606801 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15606801 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15606801 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15606801 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:15606801 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:15606801 | pubmed:author | pubmed-author:NijhuisMoniqu... | lld:pubmed |
| pubmed-article:15606801 | pubmed:author | pubmed-author:FlorquinSandr... | lld:pubmed |
| pubmed-article:15606801 | pubmed:author | pubmed-author:AkiraShizuoS | lld:pubmed |
| pubmed-article:15606801 | pubmed:author | pubmed-author:KwakkelJoanJ | lld:pubmed |
| pubmed-article:15606801 | pubmed:author | pubmed-author:SchuurmanRobR | lld:pubmed |
| pubmed-article:15606801 | pubmed:author | pubmed-author:LutterRenéR | lld:pubmed |
| pubmed-article:15606801 | pubmed:author | pubmed-author:JansenHenk... | lld:pubmed |
| pubmed-article:15606801 | pubmed:author | pubmed-author:ArensRamonR | lld:pubmed |
| pubmed-article:15606801 | pubmed:author | pubmed-author:Van Der... | lld:pubmed |
| pubmed-article:15606801 | pubmed:author | pubmed-author:Van... | lld:pubmed |
| pubmed-article:15606801 | pubmed:author | pubmed-author:Van Der... | lld:pubmed |
| pubmed-article:15606801 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15606801 | pubmed:volume | 114 | lld:pubmed |
| pubmed-article:15606801 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15606801 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15606801 | pubmed:pagination | 112-20 | lld:pubmed |
| pubmed-article:15606801 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:15606801 | pubmed:meshHeading | pubmed-meshheading:15606801... | lld:pubmed |
| pubmed-article:15606801 | pubmed:meshHeading | pubmed-meshheading:15606801... | lld:pubmed |
| pubmed-article:15606801 | pubmed:meshHeading | pubmed-meshheading:15606801... | lld:pubmed |
| pubmed-article:15606801 | pubmed:meshHeading | pubmed-meshheading:15606801... | lld:pubmed |
| pubmed-article:15606801 | pubmed:meshHeading | pubmed-meshheading:15606801... | lld:pubmed |
| pubmed-article:15606801 | pubmed:meshHeading | pubmed-meshheading:15606801... | lld:pubmed |
| pubmed-article:15606801 | pubmed:meshHeading | pubmed-meshheading:15606801... | lld:pubmed |
| pubmed-article:15606801 | pubmed:meshHeading | pubmed-meshheading:15606801... | lld:pubmed |
| pubmed-article:15606801 | pubmed:meshHeading | pubmed-meshheading:15606801... | lld:pubmed |
| pubmed-article:15606801 | pubmed:meshHeading | pubmed-meshheading:15606801... | lld:pubmed |
| pubmed-article:15606801 | pubmed:meshHeading | pubmed-meshheading:15606801... | lld:pubmed |
| pubmed-article:15606801 | pubmed:meshHeading | pubmed-meshheading:15606801... | lld:pubmed |
| pubmed-article:15606801 | pubmed:meshHeading | pubmed-meshheading:15606801... | lld:pubmed |
| pubmed-article:15606801 | pubmed:meshHeading | pubmed-meshheading:15606801... | lld:pubmed |
| pubmed-article:15606801 | pubmed:meshHeading | pubmed-meshheading:15606801... | lld:pubmed |
| pubmed-article:15606801 | pubmed:meshHeading | pubmed-meshheading:15606801... | lld:pubmed |
| pubmed-article:15606801 | pubmed:meshHeading | pubmed-meshheading:15606801... | lld:pubmed |
| pubmed-article:15606801 | pubmed:meshHeading | pubmed-meshheading:15606801... | lld:pubmed |
| pubmed-article:15606801 | pubmed:meshHeading | pubmed-meshheading:15606801... | lld:pubmed |
| pubmed-article:15606801 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15606801 | pubmed:articleTitle | Enhanced viral clearance in interleukin-18 gene-deficient mice after pulmonary infection with influenza A virus. | lld:pubmed |
| pubmed-article:15606801 | pubmed:affiliation | Laboratory of Experimental Internal Medicine, University of Amsterdam, Amsterdam, the Netherlands. | lld:pubmed |
| pubmed-article:15606801 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:16173 | entrezgene:pubmed | pubmed-article:15606801 | lld:entrezgene |
| entrez-gene:29197 | entrezgene:pubmed | pubmed-article:15606801 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15606801 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15606801 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15606801 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15606801 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15606801 | lld:pubmed |
