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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-12-20
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pubmed:abstractText |
T helper 1 driven immune responses facilitate host defence during viral infections. Because interleukin-18 (IL-18) mediates T helper 1 driven immune responses, and since mature IL-18 is up-regulated in human macrophages after influenza virus infection in vitro, it has been suggested that IL-18 plays an important role in the immune response to influenza. To determine the role of IL-18 in respiratory tract infection with influenza, IL-18 gene-deficient (IL-18(-/-)) and normal wildtype mice were intranasally inoculated with influenza A virus. Influenza resulted in an increase in constitutively expressed IL-18 in the lungs of wildtype mice. The clearance of influenza A was inhibited by IL-18, as indicated by reduced viral loads on day 8 and day 12 after infection in IL-18(-/-) mice. This enhanced viral clearance correlated with increased CD4(+) T-cell activation in the lungs as reflected by CD69 expression on the cell surface. Surprisingly, interferon-gamma (IFN-gamma) levels were similar in the lungs of IL-18(-/-) mice and wildtype mice. Intracellular IFN-gamma staining revealed similar expression levels in lung-derived natural killer cells, CD4(+) and CD8(+) T cells, indicating that IFN-gamma production is IL-18-independent during influenza virus infection. Tumour necrosis factor-alpha production by CD4(+) T cells was significantly lower in IL-18(-/-) mice than in wildtype mice. Our data indicate that endogenous IL-18 impairs viral clearance during influenza A infection.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-10358182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-10433806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-10476938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-10543274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-11136770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-11241276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-11244043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-11325600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-11447182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-11500480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-11504551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-11509635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-11751983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-12742650,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-14504095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-14556979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-14769900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-15034168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-15326478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-7666537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-8766574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-8912881,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-9449707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-9529155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-9550417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-9551984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-9637519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15606801-9971824
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0019-2805
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pubmed:author |
pubmed-author:AkiraShizuoS,
pubmed-author:ArensRamonR,
pubmed-author:FlorquinSandrineS,
pubmed-author:JansenHenk MHM,
pubmed-author:KwakkelJoanJ,
pubmed-author:LutterRenéR,
pubmed-author:NijhuisMoniqueM,
pubmed-author:SchuurmanRobR,
pubmed-author:Van Der PollsTomT,
pubmed-author:Van Der SluijsKoenraad FKF,
pubmed-author:Van EldenLeontine J RLJ
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pubmed:issnType |
Print
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
112-20
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15606801-Animals,
pubmed-meshheading:15606801-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:15606801-CD4-Positive T-Lymphocytes,
pubmed-meshheading:15606801-CD8-Positive T-Lymphocytes,
pubmed-meshheading:15606801-Cytokines,
pubmed-meshheading:15606801-Immune Tolerance,
pubmed-meshheading:15606801-Influenza A virus,
pubmed-meshheading:15606801-Interferon-gamma,
pubmed-meshheading:15606801-Interleukin-18,
pubmed-meshheading:15606801-Lung,
pubmed-meshheading:15606801-Lymphocyte Activation,
pubmed-meshheading:15606801-Mice,
pubmed-meshheading:15606801-Mice, Inbred C57BL,
pubmed-meshheading:15606801-Mice, Knockout,
pubmed-meshheading:15606801-Orthomyxoviridae Infections,
pubmed-meshheading:15606801-RNA, Messenger,
pubmed-meshheading:15606801-Survival Rate,
pubmed-meshheading:15606801-Up-Regulation,
pubmed-meshheading:15606801-Viral Load
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pubmed:year |
2005
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pubmed:articleTitle |
Enhanced viral clearance in interleukin-18 gene-deficient mice after pulmonary infection with influenza A virus.
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pubmed:affiliation |
Laboratory of Experimental Internal Medicine, University of Amsterdam, Amsterdam, the Netherlands.
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pubmed:publicationType |
Journal Article
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