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rdf:type |
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lifeskim:mentions |
umls-concept:C0008059,
umls-concept:C0021745,
umls-concept:C0023449,
umls-concept:C0033268,
umls-concept:C0205217,
umls-concept:C0683278,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1948023,
umls-concept:C2243049,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
2004-12-20
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pubmed:abstractText |
Disease-specific over-expression of 9-O-acetylated sialoglycoconjugates (9-O-AcSGs) on peripheral blood mononuclear cells (PBMC) of children with acute lymphoblastic leukaemia (ALL, PBMC(ALL)) has been demonstrated using a lectin, Achatinin-H, with specificity towards 9-O-AcSAalpha2-6GalNAc. This study investigated the contributory role of 9-O-AcSGs induced on PBMC(ALL). Stimulation of PBMC(ALL) with Achatinin-H through 9-O-AcSGs led to a lymphoproliferative response with a significantly increased interferon-gamma (IFN-gamma) production when compared with unstimulated cells as demonstrated by enzyme-linked immunosorbent assay and mRNA expression. Under identical conditions, PBMC(ALL) ablated of O-acetylations did not respond to such stimulation. In summary, it may be concluded that stimulation of over-expressed 9-O-AcSGs regulate signalling for proliferation, leading to the release of IFN-gamma. Controlled expression of these molecules may be exploited as potential targets for therapy, promising beneficial effects to children with ALL.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0007-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
128
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
35-41
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15606547-Adolescent,
pubmed-meshheading:15606547-Cell Proliferation,
pubmed-meshheading:15606547-Child,
pubmed-meshheading:15606547-Child, Preschool,
pubmed-meshheading:15606547-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:15606547-Female,
pubmed-meshheading:15606547-Flow Cytometry,
pubmed-meshheading:15606547-Glycoconjugates,
pubmed-meshheading:15606547-Humans,
pubmed-meshheading:15606547-Infant,
pubmed-meshheading:15606547-Interferon-gamma,
pubmed-meshheading:15606547-Lectins,
pubmed-meshheading:15606547-Leukocytes, Mononuclear,
pubmed-meshheading:15606547-Male,
pubmed-meshheading:15606547-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:15606547-RNA, Messenger,
pubmed-meshheading:15606547-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15606547-Sialic Acids,
pubmed-meshheading:15606547-Signal Transduction,
pubmed-meshheading:15606547-Stimulation, Chemical
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pubmed:year |
2005
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pubmed:articleTitle |
Increased interferon gamma production by peripheral blood mononuclear cells in response to stimulation of overexpressed disease-specific 9-O-acetylated sialoglycoconjugates in children suffering from acute lymphoblastic leukaemia.
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pubmed:affiliation |
Immunobiology Division, Indian Institute of Chemical Biology, 4 Raja S.C. Mullick Road, Kolkata, India.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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