Linked Life Data

15605599

Source:http://linkedlifedata.com/resource/pubmed/id/15605599

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-12-20
pubmed:abstractText
The use of different forms of human red blood cells as oral carrier systems for human insulin in vivo was the subject of this investigation. Male Wistar rats were made diabetic by a single intraperitoneal injection of streptozocin (100 mg/kg). Three days after the injection, rats were found diabetic as evidenced by elevated fasted blood glucose concentration (200 mg/dl or higher). Rats received orally one of the following (100 U, 2 ml): an insulin solution, a ghosts-insulin suspension, a vesicles-insulin suspension, a liposomes-ghosts-insulin suspension, or a liposomes-vesicles-insulin suspension. Free carrier suspensions or sodium chloride solution (0.9%) were also given orally as controls. Blood glucose concentration was determined just before administration and at 1, 2, 3, 4, 5, 6, and 7 hr post administration. The results show that all treatment groups, except liposomes-ghosts-insulin, were significantly different statistically from their respective controls (i.e., the free carriers).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0363-9045
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
67-72
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Erythrocytes as oral delivery systems for human insulin.
pubmed:affiliation
Campbell University School of Pharmacy, Buies Creek, North Carolina 27506, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't