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rdf:type |
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lifeskim:mentions |
umls-concept:C0021311,
umls-concept:C0027984,
umls-concept:C0033684,
umls-concept:C0331858,
umls-concept:C0475264,
umls-concept:C0521447,
umls-concept:C1546856,
umls-concept:C1550548,
umls-concept:C1555714,
umls-concept:C1704640,
umls-concept:C1705654,
umls-concept:C1706515,
umls-concept:C1709305
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pubmed:issue |
5
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pubmed:dateCreated |
1992-5-14
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pubmed:abstractText |
A large proportion of the Newcastle disease virus (NDV) matrix (M) protein is found in the nuclei of infected chicken embryo cells. Kinetic analysis indicated that much of the M protein enters the nucleus early in infection, concentrating in discrete regions of the nucleus and remaining there throughout infection. The M protein was found in localized regions of the nuclei of a variety of cell lines infected with NDV. Immunostaining for both M protein and nucleolar antigens indicated that most of these regions represent nucleoli. Moreover, this nucleolar localization of the M protein was observed in chicken embryo cells infected with 11 different strains of NDV. Only the M protein of strain HP displayed a modified pattern, concentrating in the nucleolus early in infection but in the cytoplasm late in infection. M protein transiently expressed in COS-1 cells also localized to the nucleus and nucleolus, indicating that the M protein does not require other NDV proteins for this localization.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-1117994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-13839220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-13844294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-179199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-1913813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-1991319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-1991323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-2108259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-2157054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-2167562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-2170233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-2668560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-2784194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-2788417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-2835230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-2845149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-2969057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-2985606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-3006337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-3027973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-3048703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-3275790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-3276076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-3530501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-3907120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-4821490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-4833608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-5021969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-5261030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-6096007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-6589587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1560547-867834
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3263-9
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1560547-Animals,
pubmed-meshheading:1560547-Antibodies, Monoclonal,
pubmed-meshheading:1560547-Biological Transport,
pubmed-meshheading:1560547-Cell Nucleolus,
pubmed-meshheading:1560547-Cell Nucleus,
pubmed-meshheading:1560547-Chick Embryo,
pubmed-meshheading:1560547-Immunoenzyme Techniques,
pubmed-meshheading:1560547-Immunohistochemistry,
pubmed-meshheading:1560547-Newcastle disease virus,
pubmed-meshheading:1560547-Viral Matrix Proteins,
pubmed-meshheading:1560547-Viral Proteins
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pubmed:year |
1992
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pubmed:articleTitle |
Nuclear entry and nucleolar localization of the Newcastle disease virus (NDV) matrix protein occur early in infection and do not require other NDV proteins.
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pubmed:affiliation |
Department of Immunology/Microbiology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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